Saffron as Therapeutic Agent for Depression: Comparative Review
Does saffron help depression?
Yes. Saffron produces antidepressant effects comparable to conventional medications like fluoxetine and imipramine, with a large effect size compared to placebo. A comprehensive review of multiple clinical trials demonstrates that saffron is as effective as standard antidepressants while offering fewer side effects, particularly regarding sexual dysfunction and weight gain.
Saffron works by blocking serotonin, norepinephrine, and dopamine reuptake, similar to conventional antidepressants, while also providing anti-inflammatory and antioxidant effects that protect brain health.
