Vortioxetine Dose-Response: 20mg Daily Shows Optimal Depression Benefits
What’s the best dose of vortioxetine for depression?
20mg daily is the optimal dose of vortioxetine for depression, providing the best balance of effectiveness and tolerability. Umbrella review shows clear dose-response relationship - higher doses work better. Key benefits:
- 20mg optimal dose - recommended for best results
- Improves multiple symptoms - depression, cognition, anxiety, quality of life
- Cognitive benefits - strongest evidence for improving thinking and memory
- Dose-response relationship - higher doses provide greater benefits
An umbrella review published in Psychiatry Research demonstrates a clear dose-response relationship for vortioxetine across all domains of major depressive disorder symptoms. The comprehensive analysis reveals that vortioxetine improves depression, cognition, anxiety, and quality of life, with higher doses providing greater benefits across all symptom domains while maintaining acceptable tolerability.