How TMS Rewires Your Brain: The Science Behind Depression Recovery
How does TMS work in the brain to treat depression?
TMS works by modulating the default mode network, a key brain system that becomes overactive in depression and contributes to negative thinking patterns. This research reveals that TMS helps normalize abnormal brain connectivity in depressed patients, particularly reducing hyperactivity in regions associated with self-focused rumination and negative thoughts.
The default mode network is a collection of brain regions that are active when we’re not focused on external tasks - essentially our brain’s “idle” state. In depression, this network becomes hyperactive and poorly regulated, leading to excessive self-focus, rumination, and negative thinking patterns that characterize depressive episodes.




