TMS for Bipolar Depression: Systematic Review and Meta-Analysis
Is TMS Effective and Safe for Bipolar Depression?
A systematic review and meta-analysis published in Biological Psychiatry Global Open Science examines the efficacy, effectiveness, and safety of transcranial magnetic stimulation for bipolar depression. Repetitive transcranial magnetic stimulation (rTMS) is cleared by the Food and Drug Administration for major depression, and recently received breakthrough status for bipolar depression (BDep). However, evidence on its efficacy and safety and optimal protocols for BDep remains limited. This comprehensive analysis synthesized available data on rTMS for bipolar depression to provide evidence-based guidance for clinical practice.