Theta Burst vs High-Frequency rTMS: THREE-D Trial Results
Is Theta Burst Stimulation as Effective as Traditional High-Frequency TMS?
The THREE-D trial published in The Lancet examines the effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression through a randomised non-inferiority trial. Treatment-resistant major depressive disorder is common; repetitive transcranial magnetic stimulation (rTMS) using high-frequency (10 Hz) left-side dorsolateral prefrontal cortex stimulation is an evidence-based treatment for this disorder. Intermittent theta burst stimulation represents a newer, potentially more efficient TMS protocol that could provide similar benefits with shorter treatment sessions.