Testosterone

Articles tagged with "Testosterone".

Defining Normal Testosterone: Harmonized Reference Ranges Across Populations

Tags: Testosterone, Reference Ranges, Hypogonadism, Endocrinology

September 16, 2025

Dr. Kumar’s Take

This study tackled a big problem: what exactly counts as “normal” testosterone? Different labs often report very different ranges, leading to confusion in diagnosis. By harmonizing data across multiple large cohorts, researchers created reference ranges that are more consistent and clinically useful. This helps doctors make clearer decisions about when low testosterone is truly low.

Key Takeaways

✔ Harmonized ranges for testosterone were established across four large population cohorts.
✔ Normal total testosterone in healthy men ranged from roughly 264 to 916 ng/dL.
✔ These ranges provide a more reliable basis for diagnosing hypogonadism.
✔ Standardization reduces variability caused by lab assay differences.

How Testosterone Therapy Improves Muscle Mass and Strength: Meta-Analysis Insights

Tags: Testosterone, Muscle, Strength, Hormones, Hypogonadism

September 16, 2025

Dr. Kumar’s Take

This meta-analysis makes it clear that testosterone therapy is not just about libido or energy. The consistent finding is that testosterone increases lean body mass and improves strength. That matters for men with hypogonadism, older adults with sarcopenia, and anyone concerned about frailty as they age. The dose, duration, and patient selection still matter, but the biological signal is strong: testosterone supports muscle health.

Key Takeaways

✔ Testosterone therapy consistently increased lean body mass in men.
✔ Strength gains were present but varied depending on the muscle group tested.
✔ The effect size was moderate, supporting clinical benefit in hypogonadal men.
✔ Longer treatment durations showed greater improvements.

Muscular Responses to Testosterone Therapy Differ by Administration Route

Tags: Testosterone, Muscle, Strength, TRT, Administration Route

September 16, 2025

Dr. Kumar’s Take

This review is important because it shows that how testosterone is given makes a difference. Injections consistently increased lean mass and strength, while gels and oral options had more mixed results. That means therapy decisions are not just about convenience, but about effectiveness. For men who need TRT primarily for muscle and strength, injectable routes may deliver the best outcomes.

Key Takeaways

✔ Testosterone injections produced the largest and most reliable increases in muscle mass.
✔ Topical gels and oral therapies showed smaller and less consistent benefits.
✔ Strength gains mirrored mass changes, with injections showing stronger effects.
✔ Route of administration should be tailored to patient goals, tolerance, and safety.

Subcutaneous Testosterone Shots Work: Effective, Stable, and Patient Preferred

Tags: Testosterone, Subcutaneous Injection, TRT, Transgender Health, Administration Route

September 16, 2025

Dr. Kumar’s Take

This study shows a simple truth. Small under the skin testosterone shots can work as well as deep muscle shots. Levels reached the target range, side effects were low, and many patients liked subcutaneous shots more because they hurt less and are easier to give at home. For men who need steady hormone support, the route you choose matters for comfort, cost, and consistency.

Key Takeaways

✔ Subcutaneous testosterone reached male-range levels reliably.
✔ Patients often preferred subcutaneous over intramuscular due to comfort and convenience.
✔ Hormone levels were stable with routine dosing schedules.
✔ Safety profile was favorable, with minimal injection site issues.

Testosterone Therapy Restores Sexual Function and Reduces Symptoms in Hypogonadal Men

Tags: Testosterone, Sexual Function, Hypogonadism, TRT, Symptoms

September 16, 2025

Dr. Kumar’s Take

This study shows why testosterone replacement can be life changing for men with hypogonadism. It doesn’t just boost lab numbers, it improves sexual desire, erectile function, and overall quality of life. Men reported feeling more like themselves again. That human outcome is often more powerful than the numbers on a lab report.

Key Takeaways

✔ Testosterone therapy significantly improved sexual desire and erectile function.
✔ Patients also reported fewer symptoms of fatigue, low mood, and poor concentration.
✔ Benefits were most consistent in men with clearly low baseline testosterone.
✔ Treatment was generally safe, with expected side effects requiring monitoring.