Muscular Responses to Testosterone Therapy Differ by Administration Route
Dr. Kumar’s Take
This review is important because it shows that how testosterone is given makes a difference. Injections consistently increased lean mass and strength, while gels and oral options had more mixed results. That means therapy decisions are not just about convenience, but about effectiveness. For men who need TRT primarily for muscle and strength, injectable routes may deliver the best outcomes.
Key Takeaways
✔ Testosterone injections produced the largest and most reliable increases in muscle mass.
✔ Topical gels and oral therapies showed smaller and less consistent benefits.
✔ Strength gains mirrored mass changes, with injections showing stronger effects.
✔ Route of administration should be tailored to patient goals, tolerance, and safety.