Which Probiotic Strains Work Best for Depression and Anxiety?
Which probiotic strains help depression and anxiety?
Lactobacillus helveticus and Bifidobacterium longum are the most effective probiotic strains for depression and anxiety. Meta-analysis found strain-specific benefits with significant improvements in both conditions.
Probiotics work by influencing the gut-brain axis, producing neurotransmitters and anti-inflammatory compounds that affect mood and anxiety pathways in the brain.
What the data show:
- Most effective strains: Lactobacillus helveticus and Bifidobacterium longum
- Strain specificity: effects vary dramatically by strain type
- Dual benefits: significant improvements in both depression and anxiety
- Evidence strength: certain Lactobacillus and Bifidobacterium species show strongest support
- Clinical importance: not all probiotics work - specific strains are required
A comprehensive meta-analysis published in Gut Pathogens found that specific probiotic strains produce significant improvements, with clear strain-specific benefits identified for mental health.