Stanford Neuromodulation Therapy: Double-Blind RCT Results
Does Stanford’s 5-day TMS protocol work for treatment-resistant depression?
Yes. Stanford’s 5-day TMS protocol works extremely well for treatment-resistant depression, achieving a 79 percent remission rate in a double-blind clinical trial.
What the data show:
- Remission rate: 79 percent vs 13 percent with sham treatment
- Treatment duration: 5 days vs traditional 6-week protocols
- Time to improvement: rapid response within days, not months
- Target population: treatment-resistant depression
- Mechanism: fMRI-guided targeting + accelerated theta-burst stimulation
A double-blind randomized controlled trial in the American Journal of Psychiatry showed that Stanford Neuromodulation Therapy (SNT) dramatically outperformed standard TMS, compressing traditional 6-week treatment into five intensive days.