Esketamine Monotherapy Shows Rapid Relief for Treatment-Resistant Depression

Can Esketamine Work Alone Without Other Antidepressants for Treatment-Resistant Depression?

Yes. Esketamine nasal spray works effectively as monotherapy for treatment-resistant depression, with significant improvements observed within 24 hours of the first dose and sustained through 28 days of treatment. A randomized clinical trial published in JAMA Psychiatry shows both 56mg and 84mg doses administered twice weekly provide rapid and clinically meaningful improvement compared to placebo, offering a standalone treatment option for patients who cannot tolerate or have not responded to oral antidepressants.

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Single-Dose Psilocybin Shows Rapid, Sustained Antidepressant Effects

Can one dose of psilocybin treat depression?

A single 25mg dose of psilocybin produces rapid and sustained antidepressant effects lasting weeks. JAMA study of 104 adults shows significant improvements compared to placebo.

Psilocybin works by activating serotonin receptors and promoting neuroplasticity, potentially resetting brain circuits involved in depression when administered with psychological support.

What the data show:

• Treatment frequency: single dose provides weeks of benefit
• Time to improvement: rapid effects seen within days, not weeks
• Duration of benefit: effects last 6+ weeks after single session
• Against placebo: significant improvements confirmed
• Paradigm shift: potential breakthrough from daily medication model

A landmark randomized, placebo-controlled trial published in JAMA demonstrates that psilocybin administered with psychological support produces significant improvement in depressive symptoms compared to placebo, offering sustained benefits from just one carefully supervised treatment session.

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