Esketamine Monotherapy Shows Rapid Relief for Treatment-Resistant Depression

Can Esketamine Work Alone Without Other Antidepressants for Treatment-Resistant Depression?

Yes. Esketamine nasal spray works effectively as monotherapy for treatment-resistant depression, with significant improvements observed within 24 hours of the first dose and sustained through 28 days of treatment. A randomized clinical trial published in JAMA Psychiatry shows both 56mg and 84mg doses administered twice weekly provide rapid and clinically meaningful improvement compared to placebo, offering a standalone treatment option for patients who cannot tolerate or have not responded to oral antidepressants.

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Single-Dose Psilocybin Shows Rapid, Sustained Antidepressant Effects

Can one dose of psilocybin treat depression?

Yes. A single 25mg dose of psilocybin produces approximately 35% greater improvement in depression symptoms compared to placebo, with effects sustained for 6 weeks. A randomized clinical trial of 104 adults with major depressive disorder found that 42% achieved sustained response with psilocybin versus 11% with placebo.

Psilocybin works by activating serotonin receptors and promoting neuroplasticity, potentially resetting brain circuits involved in depression when administered with psychological support.

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