Single-Dose Psilocybin vs Placebo: First Double-Blind Depression Trial
Does single-dose psilocybin beat placebo for depression?
Yes, single-dose psilocybin significantly outperforms placebo for depression in the first gold-standard placebo-controlled trial. Double-blind study provides definitive evidence. Key findings:
- Significantly better than placebo - first rigorous placebo-controlled trial
- Single dose - moderate dose provides rapid antidepressant effects
- Gold-standard evidence - double-blind, randomized methodology
- Rapid-acting treatment - fast relief compared to traditional antidepressants
A groundbreaking placebo-controlled, double-blind, randomized clinical trial published in eClinicalMedicine represents the first study to compare a single, moderate dose of psilocybin to placebo in major depressive disorder. This landmark trial provides the gold-standard evidence needed to establish psilocybin as a rapid-acting treatment for depression using rigorous placebo-controlled methodology.