Why Humans Lost Uricase: Evolution, Uric Acid, and Health Implications
Dr. Kumar’s Take
This study dives into the mystery of why humans and our closest primate relatives lost the enzyme uricase, which normally breaks down uric acid. The research shows that independent mutations in different ape lineages disabled this gene. As a result, humans have much higher uric acid levels compared to most mammals. While this may have offered evolutionary advantages like antioxidant protection for the brain and longer lifespan, it also increased our risk for gout and kidney disease. For modern readers, the study highlights why maintaining healthy uric acid levels is so important.