PPIs Cause Low Magnesium: Meta-Analysis Reveals 43% Higher Risk
Do Proton Pump Inhibitors Cause Dangerous Magnesium Deficiency?
Yes, proton pump inhibitors significantly increase the risk of hypomagnesemia (low magnesium levels) by 43% according to this comprehensive meta-analysis. The increased risk results from PPI-induced impairment of magnesium absorption in the intestines, particularly affecting patients on long-term therapy, and can lead to serious complications including muscle cramps, seizures, and cardiac arrhythmias.
Dr. Kumar’s Take
This meta-analysis provides solid evidence for another important PPI nutritional consequence. A 43% increased risk of magnesium deficiency is clinically significant because low magnesium can cause serious symptoms - muscle cramps, weakness, irregular heartbeats, and even seizures. What’s particularly concerning is that magnesium deficiency can be subtle initially, and by the time symptoms appear, levels may be quite low. This reinforces the importance of monitoring electrolytes in long-term PPI users and considering magnesium supplementation when appropriate.