Can a Probiotic Reduce Knee Osteoarthritis Pain? A Triple-Blind RCT Says Yes
Dr. Kumar’s Take:
A new study suggests that the probiotic Saccharomyces boulardii may be an effective adjunct therapy for knee osteoarthritis (KOA), particularly in overweight and obese individuals. The randomized, triple-blind, placebo-controlled trial demonstrated significant reductions in pain, inflammation, and oxidative stress markers, alongside improved quality of life. Given its safety profile, S. boulardii could be a promising non-pharmacologic intervention for KOA management.
Brief Summary:
A 12-week randomized, triple-blind, placebo-controlled trial investigated the effects of Saccharomyces boulardii supplementation in 70 patients with knee osteoarthritis (KOA). The primary outcome was pain intensity, measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score and the Visual Analogue Scale (VAS).