NSAIDs and Sphincter-Relaxing Drugs Increase Cancer Risk
Do NSAIDs and Sphincter-Relaxing Drugs Increase Cancer Risk?
Research shows a complex relationship between anti-inflammatory drugs and sphincter-relaxing medications and esophageal/gastric cancer risk, with effects varying by drug type, duration of use, and cancer location. While some NSAIDs may reduce gastric cancer risk, medications that relax the lower esophageal sphincter can potentially increase esophageal cancer risk by promoting chronic acid reflux and tissue damage.
Dr. Kumar’s Take
This research highlights the complex relationship between commonly used medications and cancer risk. NSAIDs have anti-inflammatory properties that might protect against some cancers, but they can also cause direct tissue damage. Sphincter-relaxing drugs are particularly concerning because they can worsen reflux, and chronic acid exposure is a known risk factor for esophageal adenocarcinoma. This doesn’t mean we should avoid these medications when medically necessary, but it reinforces the importance of using them judiciously and monitoring for side effects.