Molecular Pathways

Molecular Pathways

Articles tagged with "Molecular Pathways".

New Discoveries in How GERD Actually Develops and Progresses

Tags: GERD Mechanism, Reflux Pathophysiology, Molecular Pathways, Disease Progression

November 7, 2025

What New Research Reveals About How GERD Actually Develops?

Recent advances in GERD research reveal that gastroesophageal reflux disease involves complex dynamic mechanisms beyond simple acid exposure, including inflammatory cascades, neural pathway disruptions, and molecular changes that create a self-perpetuating cycle of tissue damage and symptom progression. These discoveries are reshaping our understanding of why GERD develops and how it should be treated.

Dr. Kumar’s Take

This research represents a paradigm shift in how we understand GERD. Instead of viewing it as simply “too much acid,” we now see it as a complex disease involving inflammation, nerve dysfunction, and cellular changes that feed on each other. This explains why some patients don’t respond well to acid suppression alone and why GERD can be so persistent. Understanding these mechanisms opens doors to more targeted treatments that address the root causes rather than just symptoms.

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