Magnesium Supplementation for Depression: Systematic Review and Meta-Analysis
Can Magnesium Supplements Help Treat Depression?
A systematic review and meta-analysis examines how magnesium supplementation beneficially affects depression in adults with depressive disorder through randomized clinical trials. Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body, including many that affect brain function and mood regulation. Despite its importance, magnesium deficiency is surprisingly common, with studies suggesting that many adults don’t consume adequate amounts through their diet. This comprehensive analysis evaluated the accumulated evidence from multiple clinical trials to determine whether magnesium supplementation can provide meaningful benefits for people with depression.