Magnesium Supplementation Benefits Depression: Meta-Analysis
Does Magnesium Supplementation Really Help Depression?
A systematic review and meta-analysis published in PMC demonstrates that magnesium supplementation beneficially affects depression in adults with depressive disorder through evidence from randomized clinical trials. Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body, including those critical for neurotransmitter synthesis, neural function, and stress response regulation. This comprehensive analysis synthesizes evidence from multiple clinical trials to determine whether magnesium supplementation provides meaningful therapeutic benefits for people with depression, addressing an important question about nutritional interventions for mental health.