Why Perimenopause Triggers Depression and How to Treat It
Why Do So Many Women Develop Depression During Perimenopause?
Hormonal fluctuations during perimenopause directly trigger depression in up to 30% of women, even those with no prior history of mood disorders. The dramatic swings in estrogen and progesterone levels disrupt neurotransmitter systems, particularly serotonin and GABA, creating a biological vulnerability to depression that’s distinct from life circumstance-related mood changes.
Dr. Kumar’s Take
Perimenopausal depression is one of the most misunderstood and undertreated conditions in women’s health. Too often, women are told their mood changes are “just stress” or “part of getting older,” when in reality they’re experiencing a hormonally-driven medical condition that responds well to appropriate treatment. The tragedy is that many women suffer for years with antidepressants that don’t address the root cause, when hormone therapy could provide more targeted and effective relief.