PPI Use Tripled in US Adults: 20-Year Trend Analysis
How Much Has PPI Use Increased Among US Adults?
Proton pump inhibitor use among US adults has increased dramatically over the past two decades, with usage rates tripling from 1999 to 2018 according to this comprehensive population analysis. This trend reflects both increased recognition of acid-related disorders and potentially inappropriate prescribing, raising important questions about the balance between therapeutic benefits and long-term safety risks in the growing population of PPI users.