Antidepressant Weight Gain: Why It Happens and How to Prevent It
Why Do Antidepressants Cause Weight Gain and How Can It Be Prevented?
A comprehensive review published in Archives of Clinical and Biomedical Research reveals that antidepressants cause weight gain in 55-65% of patients through multiple biological mechanisms including altered neurotransmitter signaling, metabolic changes, and appetite regulation disruption. This adverse effect contributes to treatment discontinuation, depression relapse, and worsened metabolic health outcomes, including increased risk for obesity and type 2 diabetes, making understanding and mitigation strategies crucial for long-term treatment success.