Magnesium Supplementation Benefits Depression: Meta-Analysis

Does Magnesium Supplementation Really Help Depression?

A systematic review and meta-analysis published in PMC demonstrates that magnesium supplementation beneficially affects depression in adults with depressive disorder through evidence from randomized clinical trials. Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body, including those critical for neurotransmitter synthesis, neural function, and stress response regulation. This comprehensive analysis synthesizes evidence from multiple clinical trials to determine whether magnesium supplementation provides meaningful therapeutic benefits for people with depression, addressing an important question about nutritional interventions for mental health.

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Magnesium Supplementation for Depression: Systematic Review and Meta-Analysis

Can Magnesium Supplements Help Treat Depression?

A systematic review and meta-analysis examines how magnesium supplementation beneficially affects depression in adults with depressive disorder through randomized clinical trials. Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body, including many that affect brain function and mood regulation. Despite its importance, magnesium deficiency is surprisingly common, with studies suggesting that many adults don’t consume adequate amounts through their diet. This comprehensive analysis evaluated the accumulated evidence from multiple clinical trials to determine whether magnesium supplementation can provide meaningful benefits for people with depression.

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Role of Magnesium Supplementation in Depression Treatment: RCT

Does magnesium help depression?

Yes. Magnesium supplementation significantly improves depression symptoms within 2 weeks. Randomized controlled trial shows meaningful benefits compared to placebo.

What the data show:

• Time to improvement: significant benefits within 2 weeks
• Against placebo: clinically meaningful symptom reduction
• Safety profile: minimal side effects, low cost, natural approach
• Combined treatment: effective add-on therapy with medications
• Mechanism: neurotransmitter synthesis support + stress response regulation

A clinical trial published in PLOS ONE found that magnesium supplementation produced clinically meaningful improvements in depressive symptoms compared to placebo control, providing gold-standard RCT evidence for this treatment approach.

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