Omega-3 for Inflamed Depression: Match/Mismatch Study Reveals Key Insights
Do omega-3s work better for inflamed depression?
Omega-3 supplements work significantly better for patients with inflamed depression compared to non-inflamed depression. Match/mismatch study identifies inflammation biomarkers that predict treatment response.
Omega-3s work by reducing inflammation that drives depression in inflamed patients, with inflammatory biomarkers identifying which patients are most likely to benefit from this personalized approach.
What the data show:
- Inflamed depression: high inflammation predicts omega-3 effectiveness
- Biomarker guidance: inflammatory markers identify ideal candidates
- Personalized approach: matches treatment to individual inflammatory profile
- Precision medicine: avoids treating patients unlikely to respond
- Treatment matching: identifies which patients benefit most from omega-3s
A groundbreaking match/mismatch study published in Brain, Behavior, and Immunity examined omega-3 fatty acids using inflammatory biomarkers to predict response, determining which depression patients are most likely to benefit based on their specific inflammatory profile.