Losartan Lowers Uric Acid by Blocking URAT1 in Hypertensive Patients

Dr. Kumar’s Take:

This study highlights something unique about losartan compared to other blood pressure medicines. Losartan not only lowers blood pressure, it also lowers uric acid by blocking a kidney transporter called URAT1. For patients with both hypertension and gout risk, this dual effect is an important advantage.

Key Takeaways:

✔ Losartan lowered uric acid levels while reducing blood pressure.
✔ The effect is linked to blocking the kidney transporter URAT1.
✔ Candesartan, another blood pressure drug, lowered blood pressure but had no effect on uric acid.
✔ Patients with defective URAT1 genes did not benefit from losartan’s uric acid effect.

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How Uric Acid Shaped Human Evolution and Fuels Hypertension Today

Dr. Kumar’s Take:

This study reveals something fascinating: a mutation millions of years ago raised uric acid levels in our ancestors, helping them maintain blood pressure when dietary salt was scarce. That survival tool has now turned into a vulnerability. In today’s high-salt world, the same elevated uric acid contributes to salt-sensitive hypertension, kidney damage, and heart disease.

Key Takeaways:

✔ Humans lost uricase, the enzyme that lowers uric acid, during the Miocene era.
✔ Higher uric acid helped maintain blood pressure in low-salt diets but now drives hypertension.
✔ Animal studies show uric acid directly raises blood pressure by activating the renin-angiotensin system and damaging kidney vessels.
✔ Modern high-salt diets make this ancient adaptation harmful.

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How Our Ancestors' Genes May Be Fueling Today’s Heart Disease

Dr. Kumar’s Take:

This fascinating study explores how traits that once helped our ancestors survive—like high cholesterol levels or better salt retention—may now be working against us. These genetic adaptations, once useful in fighting off infections or surviving heat and dehydration, are mismatched with today’s lifestyle of overnutrition and processed food. The result? Increased risk for heart disease, high blood pressure, and stroke.

Actionable tip: If heart disease runs in your family, it may not just be diet—your genes might be playing a role. But healthy lifestyle choices like reducing processed foods, staying active, and managing stress can help offset these inherited risks.

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Which Blood Pressure Medications Work Best? A Look at the Latest Research

Dr. Kumar’s Take:

A network meta-analysis published in JAMA Network Open reviewed 46 randomized clinical trials to compare the effectiveness of different blood pressure medications in reducing cardiovascular events. The findings suggest that while most medications are effective, some may be better suited for specific cardiovascular outcomes. For patients with high blood pressure, these results reinforce the importance of selecting the right medication based on individual risk factors.

Actionable Tip: If you’re taking antihypertensive medication, it’s crucial to work with your doctor to ensure you’re on the most effective drug for your specific cardiovascular risks.

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