Coffee Prevents Liver Cancer: Meta-Analysis of 16 Studies
Dr. Kumar’s Take
Among all organ systems, the liver shows some of the most consistent and powerful associations with coffee. Multiple cohort and meta-analytic studies demonstrate reduced risk of hepatocellular carcinoma (HCC) and chronic liver disease among regular coffee drinkers. The magnitude of benefit is impressive, and appears independent of alcohol intake or viral hepatitis status.
Key Takeaways
- Each additional cup of coffee per day is linked to ~15% lower risk of liver cancer in pooled analyses.
- Chronic liver disease incidence and mortality decline in higher-intake groups.
- Benefits persist for decaf coffee, suggesting a role for polyphenols and diterpenes beyond caffeine.
- Mechanisms include antioxidant, anti-fibrotic, and insulin-sensitizing effects on hepatic metabolism.
Actionable Tip
Regular coffee — 2–4 cups daily — may contribute to liver protection, especially for individuals with fatty liver or metabolic syndrome risk factors.