Saffron as Add-On Therapy to Sertraline for Generalized Anxiety Disorder
Can Saffron Enhance Sertraline’s Effectiveness for Anxiety Disorders?
A double-blind randomized controlled trial published in Archives of Neuroscience examined the effect of saffron (Crocus sativus L.) as an add-on therapy to sertraline in mild to moderate generalized anxiety disorder. This innovative study investigated whether combining the traditional spice saffron with the SSRI antidepressant sertraline could provide superior therapeutic benefits compared to sertraline alone. The research addresses an important clinical question about augmentation strategies for anxiety disorders and the potential role of natural compounds in enhancing conventional psychiatric treatments.