Large PPI-Induced Gastric Polyps Can Disappear in 2 Months
Can Large PPI-Induced Gastric Polyps Actually Disappear?
Yes, even large proton pump inhibitor-induced gastric polyps can completely regress within as little as 2 months after PPI discontinuation, as demonstrated in these remarkable case reports. This rapid regression occurs because PPI-induced polyps are primarily hyperplastic responses to chronic hypergastrinemia rather than true neoplastic growths, allowing them to resolve quickly once the underlying stimulus is removed.
Dr. Kumar’s Take
These cases are remarkable because they show just how reversible PPI-induced changes can be. Even large polyps that might seem concerning can completely disappear in just 2 months - that’s incredibly fast for any tissue change in the body. This reinforces that PPI-induced polyps are fundamentally different from other gastric polyps. They’re essentially an overgrowth response to chronic gastrin stimulation, not true tumors. This gives us confidence that when PPI discontinuation is possible, even dramatic-looking polyps can resolve completely.