Intrinsic Factor: The Stomach Protein Essential for B12 Absorption
What Is Intrinsic Factor and Why Is It Essential for Health?
Intrinsic factor is a glycoprotein produced by gastric parietal cells that is absolutely essential for vitamin B12 absorption in the small intestine. Without adequate intrinsic factor, the body cannot absorb vitamin B12 from food, leading to pernicious anemia and potentially severe neurological complications. This critical protein demonstrates how stomach health directly impacts overall nutrition and highlights why conditions affecting parietal cells can have far-reaching health consequences.