H. Pylori and GERD: Friend or Foe? The Complex Relationship
Does H. Pylori Infection Protect Against or Cause GERD?
The relationship between Helicobacter pylori and GERD is complex and paradoxical - H. pylori infection can both protect against and contribute to reflux disease depending on the bacterial strain, infection location, and individual host factors. This dual nature explains conflicting research findings and has important implications for treatment decisions in patients with both conditions.
Dr. Kumar’s Take
This research reveals one of the most fascinating paradoxes in gastroenterology. H. pylori can actually protect against GERD by reducing acid production, but it can also worsen reflux in certain circumstances. The key is understanding that not all H. pylori infections are the same - the bacterial strain, where it lives in the stomach, and the individual’s immune response all matter. This complexity explains why some patients develop GERD after H. pylori eradication and why treatment decisions need to be individualized.