Comprehensive Review: PPIs and Bone Health Risks
What Does the Complete Evidence Say About PPIs and Bone Health?
This comprehensive umbrella review confirms that proton pump inhibitors are associated with increased risks of osteoporosis, fractures, and impaired bone metabolism, with effects being most pronounced in elderly patients and those on long-term therapy. The evidence consistently demonstrates that PPIs affect bone health through multiple mechanisms including impaired calcium absorption, altered bone remodeling, and potential direct effects on bone cells.