HBOT Effects on Mitochondrial Function and Athletic Performance: RCT
Can Hyperbaric Oxygen Therapy Improve Fitness in Middle-Aged Athletes?
Yes. This double-blind randomized controlled trial found 40 sessions of HBOT significantly improved VO2max (effect size 0.99), anaerobic threshold (effect size 0.84), mitochondrial respiratory capacity (effect size 1.09), and increased mitochondrial mass by 17% compared to -9% in controls. This is the first blinded RCT to demonstrate HBOT enhances athletic performance.
Previous studies suggested hyperbaric oxygen might enhance performance, but none used proper placebo controls. This Israeli study used rigorous double-blinding, muscle biopsies to measure mitochondrial changes, and cardiopulmonary exercise testing to assess real-world performance.











