Evidence-Based Medicine

Articles tagged with "Evidence-Based Medicine".

Benefits of Supplemental Oxygen in Exercise Training In

Tags: Exercise Recovery, Cold Therapy, Evidence-Based Medicine

January 20, 2026

Does Oxygen During Exercise Training Help COPD Patients Who Don’t Need It at Rest?

Yes. This double-blind trial found that supplemental oxygen during high-intensity exercise training allows COPD patients to train harder and achieve greater improvements in endurance. Patients who trained with oxygen increased endurance time by 14.5 minutes compared to 10.5 minutes in the air group.

People with COPD often struggle with exercise, even when their oxygen levels at rest are normal. Researchers tested whether breathing extra oxygen during training would help these patients exercise more intensively and get better results.

Breaking the Hypoxia Barrier: HBOT in Cancer Treatment

Tags: Oncology, Drug Therapy, Research Review, Evidence-Based Medicine

January 20, 2026

Can Hyperbaric Oxygen Therapy Help Cancer Treatments Work Better?

Yes. This 2025 comprehensive review found that hyperbaric oxygen therapy enhances chemotherapy, radiotherapy, and immunotherapy by addressing the low-oxygen environment inside tumors. In one study, combining HBOT with radiotherapy improved response rates from 67.4% to 95.3% for brain metastases.

Tumors create low-oxygen zones deep inside them. This low oxygen helps cancer cells resist treatment and spread. HBOT floods the body with oxygen under pressure, reaching areas that normal blood flow cannot. This review pulls together evidence from dozens of studies showing how HBOT can boost standard cancer treatments.

Hyperbaric Oxygen Therapy on Long Covid: Systematic Review

Tags: Cold Therapy, Drug Therapy, Research Review, Evidence-Based Medicine

January 20, 2026

Can Hyperbaric Oxygen Therapy Help Long COVID Symptoms?

Yes, with caveats. This systematic review of 10 studies found that HBOT can improve quality of life, fatigue, cognition, neuropsychiatric symptoms, and heart/lung function in long COVID patients. However, more rigorous trials are needed before making definitive recommendations.

Long COVID affects an estimated 20-50% of people after COVID-19 infection. Symptoms like fatigue, brain fog, and shortness of breath can last for weeks or months. Hyperbaric oxygen therapy (HBOT) has shown promise as a treatment, but how strong is the evidence?

Hypoxia and Inflammation: Two Sides of the Same Coin

Tags: Immune Function, Evidence-Based Medicine

January 20, 2026

Are Hypoxia and Inflammation Really Connected?

Yes. This PNAS commentary explains that hypoxia (low oxygen) and inflammation are deeply linked in a two-way relationship. When tissues lack oxygen, they become inflamed. When tissues become inflamed, they often become oxygen-deprived. Understanding this connection opens doors to new treatments.

Scientists have discovered that the same proteins controlling your body’s response to low oxygen also control inflammation. This means drugs that target oxygen-sensing pathways could help treat inflammatory diseases. A recent clinical trial has already shown these compounds can be used safely in patients.

Hypoxia as Therapy for Mitochondrial Disease

Tags: Metabolic Health, Clinical Trial, Evidence-Based Medicine

January 20, 2026

Can Low Oxygen Treat Mitochondrial Disease?

Yes, surprisingly. This groundbreaking Science study found that mice with Leigh syndrome (a fatal mitochondrial disease) had dramatically extended lifespans when breathing 11% oxygen. All untreated mice died by 75 days. Hypoxia-treated mice had NO deaths, with the oldest surviving past 170 days. Conversely, breathing 55% oxygen killed diseased mice within 2-11 days.

This counterintuitive finding challenges how we think about oxygen and cellular health. The researchers discovered that activating the body’s natural hypoxia response protects cells with faulty mitochondria.

Long Covid Brain Fog and Csf Abnormalities and Safety

Tags: Neurology, Evidence-Based Medicine

January 20, 2026

Does Long COVID Brain Fog Show Up in Spinal Fluid Tests?

Yes. In this study, 77% of patients with cognitive Long COVID symptoms had abnormal spinal fluid findings, compared to 0% of those without cognitive symptoms. Researchers also found that people with cognitive Long COVID had more pre-existing risk factors for thinking problems.

This study from UCSF examined adults who developed persistent cognitive symptoms after mild COVID-19, meaning they were never hospitalized. The findings suggest that immune system changes may play a role in Long COVID brain fog.

Long Covid Symptom Prevalence Study

Tags: Research Review, Evidence-Based Medicine

January 20, 2026

What Are the Most Common Long COVID Symptoms?

Fatigue is the most common, affecting 47% of Long COVID patients. This comprehensive review of 27 studies found that shortness of breath (32%), muscle pain (25%), and joint pain (20%) were also highly prevalent. About 1 in 5 people have symptoms for 5 weeks or more, and 1 in 10 experience them beyond 12 weeks.

This review from the Journal of the Royal Society of Medicine analyzed the current evidence on Long COVID symptoms, complications, and management. The findings reveal that persistent symptoms occur regardless of how severe the initial COVID-19 infection was.

Long-term Oxygen Treatment Trial Lott and Health Benefits

Tags: Exercise Recovery, Clinical Trial, Evidence-Based Medicine

January 20, 2026

Does Long-Term Oxygen Help COPD Patients with Moderate Low Oxygen Levels?

No. This landmark trial of 738 COPD patients found that long-term supplemental oxygen did not reduce death or hospitalization rates for patients with moderate oxygen desaturation. There was also no benefit for quality of life, lung function, or walking distance.

For decades, doctors have prescribed oxygen therapy to COPD patients with moderately low oxygen levels, assuming it would help. This large trial from the New England Journal of Medicine tested whether that assumption was correct.

Oxygen Desaturation in Recovered Covid Patients and Physiology

Tags: Exercise Recovery, Cold Therapy, Evidence-Based Medicine

January 20, 2026

Can Normal Oxygen Levels at Rest Hide Exercise Problems After COVID?

Yes. In this study, 43% of COVID pneumonia patients with normal oxygen at rest showed significant oxygen drops during a walking test. Normal blood gas readings at discharge cannot predict whether patients will struggle with exercise.

Researchers in Italy studied 70 patients ready for discharge after COVID-19 pneumonia. Even though all had normal oxygen levels at rest, nearly half experienced significant oxygen desaturation when they exercised. Most concerning, 83% of those who desaturated dropped below 90% oxygen during the test.

Supervised Rehabilitation for Long Covid 30 Patients

Tags: Exercise Recovery, Evidence-Based Medicine

January 20, 2026

Can Rehabilitation Help People with Long COVID?

Yes. In this study, 30 people with Long COVID who completed a 6-week rehabilitation program showed significant improvements in exercise capacity, fatigue, breathing symptoms, and cognition. Walking distance improved by 112 meters, and there were no serious adverse events.

This UK study tested whether an adapted pulmonary rehabilitation program could safely help people struggling with lasting COVID-19 symptoms. The results showed clear benefits across multiple measures of function and quality of life.

Tumor Oxygenation and Survival Rates 22 Sarcoma Patients

Tags: Oncology, Surgery, Evidence-Based Medicine

January 20, 2026

Does Tumor Oxygen Level Predict Cancer Spread?

Yes. In this study of 22 sarcoma patients, tumors with low oxygen levels were twice as likely to spread to the lungs. Disease-free survival at 18 months was 70% for well-oxygenated tumors but only 35% for hypoxic tumors.

Researchers at Duke University Medical Center measured oxygen levels directly inside soft tissue sarcomas before treatment. They found that oxygen level was a strong predictor of whether the cancer would spread, independent of tumor size.

Age-dependence of Oxygen Transport Into Body Tissues and The

Tags: Exercise Recovery, Cold Therapy, Drug Therapy, Evidence-Based Medicine

January 20, 2026

Does Aging Reduce Oxygen Delivery to Your Tissues?

Yes. Oxygen transport into body tissues declines with age, primarily due to reduced heart output. However, Oxygen Multistep Therapy may counteract this decline by activating a “switch mechanism” that improves blood circulation for weeks, months, or even years.

This research describes how oxygen levels in your blood control a switching mechanism in your tiny blood vessels. When oxygen levels are high enough, your blood circulation improves and stays improved. When they fall below a critical threshold, circulation decreases for extended periods.