EPA Supplementation for Depression: Pro-Resolving Lipid Mediators Key to Response
Why do some people respond to EPA supplements for depression?
People who respond to EPA supplements have significantly higher levels of pro-resolving lipid mediators in their blood, particularly at the 4 gram/day dose where response rates were substantially higher than placebo. A study published in Neuropsychopharmacology shows these specialized molecules reduce inflammation and explain why omega-3s work for some but not others, with responders showing greater increases in anti-inflammatory mediators.