Defining Normal Testosterone: Harmonized Reference Ranges Across Populations
Dr. Kumar’s Take
This study tackled a big problem: what exactly counts as “normal” testosterone? Different labs often report very different ranges, leading to confusion in diagnosis. By harmonizing data across multiple large cohorts, researchers created reference ranges that are more consistent and clinically useful. This helps doctors make clearer decisions about when low testosterone is truly low.
Key Takeaways
✔ Harmonized ranges for testosterone were established across four large population cohorts.
✔ Normal total testosterone in healthy men ranged from roughly 264 to 916 ng/dL.
✔ These ranges provide a more reliable basis for diagnosing hypogonadism.
✔ Standardization reduces variability caused by lab assay differences.