The Effect of Vitamin D Supplementation on Depressive Symptoms in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Introduction
This comprehensive systematic review and meta-analysis examined the efficacy of vitamin D supplementation in reducing depressive symptoms among adults. With depression affecting more than 320 million people worldwide and being the leading cause of disability globally, identifying effective adjunctive treatments is crucial for improving patient outcomes.
Background and Rationale
Vitamin D and Depression Connection
Vitamin D, traditionally known for its role in bone health, has emerged as a potential neurosteroid with significant implications for mental health. Following the discovery of vitamin D receptors in the brain, researchers have investigated its potential role in regulating neurophysiological processes associated with depression.