Depression RCT

Depression RCT

Articles tagged with "Depression RCT".

Wim Hof Method for Depression: Randomized Clinical Trial

Tags: Wim Hof Method, Depression RCT, Breathing Techniques, Cold Exposure Therapy

November 23, 2025

Does the Wim Hof Method help women with depression?

Both the Wim Hof Method and slow-paced breathing interventions produced equivalent improvements in depression, with a 24% reduction in depressive symptoms and 27% reduction in anxiety symptoms after 3 weeks. A randomized controlled trial of 84 women with high depressive symptoms found that improvements were maintained at 3-month follow-up, with 46% of participants reporting mild or no depressive symptoms.

The Wim Hof Method works by combining rapid breathing and breath-holding to induce intermittent hypoxia, along with cold exposure, which together create hormetic stress responses that may help normalize the stress response system and reduce rumination.

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