Ascorbic Acid Boosts Collagen Production in Human Fibroblasts
Dr. Kumar’s Take
In this study researchers found that vitamin C increases collagen production almost eight times in human skin cells. They discovered that vitamin C does more than help enzymes add hydroxyl groups—it also boosts overall collagen protein made by cells. For readers this means ensuring good vitamin C intake may help maintain healthy connective tissue and support wound healing.
Key Takeaways
✔ Vitamin C increased collagen synthesis about eight-fold in human skin fibroblasts.
✔ Lysyl hydroxylase enzyme activity rose three-fold while prolyl hydroxylase activity decreased after prolonged exposure.
✔ Collagen hydroxylation and overall collagen production are regulated separately by vitamin C.
✔ Underhydroxylated collagen is unstable and accumulates inside cells.