The STAR*D Trial: Why Current Depression Treatments Aren't Working
What did the STAR*D trial reveal about depression treatment effectiveness?
The STAR*D trial revealed that current depression treatments are far less effective than commonly believed, with only 37% achieving remission after multiple attempts. Landmark study shows success rates drop dramatically with each treatment attempt.
The trial found that despite extensive antidepressant use, there is no evidence of meaningful decreases in suicide rates or disability from depression at the population level.