Why Cancer Causes Depression: The Tryptophan-Inflammation Connection

How Does Cancer-Related Inflammation Cause Depression and Fatigue?

Cancer-related inflammation activates enzymes that break down tryptophan through the kynurenine pathway instead of converting it to serotonin, leading to serotonin depletion and the production of neurotoxic metabolites. This biochemical shift directly contributes to the depression, fatigue, and cognitive symptoms commonly experienced by cancer patients, creating a vicious cycle where inflammation worsens mood, which can further impair immune function and treatment outcomes.

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Unlocking Vitamin C’s Cancer-Fighting Mechanisms

Dr. Kumar’s Take:

This review shows that vitamin C may help in cancer treatment in three main ways. First, high doses of vitamin C can make hydrogen peroxide that may kill cancer cells. Second, vitamin C helps key enzymes work that slow tumor growth when oxygen is low. Third, vitamin C supports enzymes that control gene activity so cancer cells can behave more normally. For readers, focus on a diet rich in vitamin C and talk to your doctor about clinical studies of high-dose vitamin C.

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Vitamin D: A Potential Ally in Cancer Prevention

Dr. Kumar’s Take:

Recent research suggests that vitamin D may play a significant role in reducing the risk of various cancers. By maintaining adequate vitamin D levels through sensible sun exposure, diet, and supplements, individuals can potentially lower their cancer risk.

Brief Summary:

A comprehensive review examined the relationship between vitamin D and cancer, highlighting:

• Ecological studies found that areas with higher sunlight exposure had lower rates of about 23 different cancers.
• Observational studies showed that higher blood levels of 25-hydroxyvitamin D were linked to a reduced risk of 12 types of cancer.
• Laboratory experiments demonstrated that vitamin D compounds could inhibit cancer cell growth and spread.
• However, some clinical trials did not show a significant benefit, possibly due to design limitations.

Key Takeaways:

✔ Higher vitamin D levels are associated with a lower risk of several cancers.
✔ Vitamin D may inhibit tumor growth and prevent cancer cells from spreading.
✔ More well-designed clinical trials are needed to confirm these findings.

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