N-Acetylcysteine for Major Mental Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Introduction
This systematic review and meta-analysis examined the efficacy of N-acetylcysteine (NAC) supplementation for major mental disorders, including depression, bipolar disorder, and schizophrenia. NAC, a precursor to glutathione and modulator of glutamate neurotransmission, has emerged as a promising adjunctive treatment for various psychiatric conditions.
Background and Rationale
N-Acetylcysteine: Mechanisms of Action
Glutathione Precursor:
- NAC is a precursor to glutathione, the brain’s primary antioxidant
- Restores glutathione levels depleted in psychiatric disorders
- Provides neuroprotection against oxidative stress
Glutamate Modulation: