Can Preventing Strep Help Kids with PANDAS? A Closer Look at Prophylactic Antibiotics
Dr. Kumar’s Take:
This study from the National Institute of Mental Health (NIMH) explored whether giving antibiotics could prevent strep-triggered neuropsychiatric flares in children with PANDAS. While the approach was well-structured and targeted, the overall results showed only modest benefit. However, for children with a strong pattern of symptom worsening after strep infections, this research supports considering prophylactic antibiotics as part of a carefully monitored plan.
Key Takeaways:
✔ Study included 37 children with PANDAS over a one-year period.
✔ Participants received either penicillin or azithromycin to prevent strep infections.
✔ Antibiotics slightly reduced strep infections, but did not significantly reduce neuropsychiatric flares.
✔ Strict monthly monitoring and symptom scoring were used to track changes.
✔ If a child developed a strep infection during the study, their study antibiotic was paused and treated with another class of antibiotic.
