SAMe as Adjuvant Therapy for Depression: Updated Meta-Analysis
Is SAMe an Effective Add-On Treatment for Depression?
An updated systematic review and meta-analysis published in PubMed examines S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression. SAMe is a naturally occurring compound involved in methylation reactions throughout the body, including neurotransmitter synthesis and regulation. This comprehensive analysis synthesizes the latest evidence on SAMe’s effectiveness when used alongside conventional antidepressant treatments, providing updated insights into its potential role as an augmentation strategy for patients with depression who have not achieved optimal response with standard therapies alone.