Health Systems

Explore health from a systems-based perspective. Each system connects research, podcast episodes, and practical insights.

21 Antidepressants Compared: Which Work Best for Depression?

5HT2A Receptors in Brain's Anterior Cingulate: Key to Psychedelic Therapy

Antidepressant Weight Gain: Why It Happens and How to Prevent It

Antidepressants vs Placebo: Why the Gap Is Narrowing in Modern Trials

Behavioral Activation Changes Brain Networks in Depression Treatment

Brexanolone Rapidly Improves Postpartum Depression, Anxiety, and Sleep

Bright Light Therapy for Teen Depression: JAMA Trial Results

CBT vs All Other Depression Treatments: Massive Meta-Analysis of 409 Trials

Chemical Imbalance Theory: Was It Really Just an 'Urban Legend'?

Circadian Light Therapy for Young People with Depression: Systematic Review

Circadian Rhythms and Depression: Time to See the Light

Citalopram in Real-World Depression: STAR*D Reveals 28% Remission Rate

Depression Management in Primary Care: Clinical Update and Best Practices

Depression Screening Guidelines: When and How to Screen Patients

Depression Treatment Cascade: How Primary Care Can Bridge the Mental Health Gap

Diet Interventions for Depression: Evidence-Based Practice Recommendations

EPA Supplementation for Depression: Pro-Resolving Lipid Mediators Key to Response

Esketamine Monotherapy Shows Rapid Relief for Treatment-Resistant Depression

How CBT Changes the Depressed Brain: fMRI Study Reveals Neural Mechanisms

How Different CBT Components Target Specific Brain Mechanisms

HPA Axis and Depression Across Women's Reproductive Life

Internet-Based CBT Self-Help: Long-Term Depression Benefits Proven

L-Theanine Adjunct to Sertraline for Major Depression: RCT

L-Theanine Supplementation for Mental Disorders: Systematic Review

Light Therapy for Dementia: Meta-Analysis Shows Benefits for Sleep, Depression, and Cognition

LSD for Depression: Mechanisms and Therapeutic Potential Revealed

Magnesium Supplementation Benefits Depression: Meta-Analysis

Major Depressive Disorder: Comprehensive Overview of Causes, Treatment, and Outcomes

Measurement-Based Care: The Simple Strategy Transforming Mental Health Treatment

Mindfulness-Based Cognitive Therapy Prevents Depression Relapse: Individual Patient Meta-Analysis

Omega-3 Fatty Acids Restore Balance on Gut-Brain Axis for Depression

Omega-3 for Inflamed Depression: Match/Mismatch Study Reveals Key Insights

Optimal Exercise Dose for Depression in Older Adults: Network Meta-Analysis

Over-the-Counter Products for Depression, Anxiety, and Insomnia in Older Adults

PHQ-9 Depression Screening: How Accurate Is This 9-Question Test?

Phytochemicals for Depression: Systematic Review of Plant-Based Treatments

Psilocybin-Assisted Therapy: Johns Hopkins Trial Shows Major Depression Relief

Psychotherapy vs Antidepressants for Depression in Heart Failure Patients

Real-World Brexanolone Outcomes: 12-Month Follow-Up Shows Sustained Benefits

Saffron as Add-On Therapy to Sertraline for Generalized Anxiety Disorder

SAMe as Adjuvant Therapy for Depression: Updated Meta-Analysis

SAMe Augmentation in Major Depressive Disorder: Clinical Trial

Sequential Therapy: Adding Psychotherapy After Antidepressants Reduces Relapse Risk

Serotonin Theory of Depression: Landmark Review Challenges Chemical Imbalance Model

Single-Dose Psilocybin Shows Rapid, Sustained Antidepressant Effects

Single-Dose Psilocybin vs Placebo: First Double-Blind Depression Trial

Social Connection: Critical Factor for Mental and Physical Health

Social Isolation and Loneliness Trigger Chronic Inflammation Across the Lifespan

St. John's Wort (Hypericum perforatum) for Depression: Documentary Analysis

STAR*D Treatment Steps: Remission Rates Drop from 37% to 13% with Each Attempt

STAR*D Trial Implications for Primary Care: What Family Doctors Need to Know

Switching to Vortioxetine Improves Antidepressant Sexual Side Effects

The Neuroscience of Loneliness: How Social Isolation Affects the Brain

The STAR*D Trial: Why Current Depression Treatments Aren't Working