Does the Trigeminal Cardiac Reflex Affect Blood Flow to the Brain?
Yes. This review shows that stimulating facial nerves triggers a powerful reflex that changes both heart rate and blood flow to the brain. When researchers activated this reflex in rats using jaw extension, they observed blood pressure drops and prolonged dilation of brain blood vessels lasting up to 3 hours.
The trigeminal cardiac reflex (TCR) is a well-known phenomenon in surgery. When facial nerves are stimulated, heart rate and blood pressure drop. This review explores something less understood: how this reflex also affects blood flow to the brain.
Dr. Kumar’s Take
This research connects two important concepts. We know cold water on the face triggers the diving reflex. We know the trigeminal cardiac reflex can cause heart rate drops during surgery. Now we’re learning that these reflexes also affect brain blood flow. The finding that a simple jaw stretch can dilate brain blood vessels for hours is remarkable. This suggests that trigeminal nerve stimulation might have therapeutic potential beyond what we previously understood.
The Diving Reflex Connection
The diving reflex is the most common way people experience the trigeminal cardiac reflex. When your face contacts cold water, several things happen:
- Heart rate slows (bradycardia)
- Blood vessels in your arms and legs constrict
- Blood pressure rises
- Blood shifts toward the heart and brain
- Oxygen consumption decreases
The colder the water, the stronger these responses become. In diving mammals like seals and whales, this reflex helps them survive extended periods underwater.
New Discovery: Jaw Extension Effects
Researchers found that a simple 10-minute jaw stretch in rats triggered impressive physiological changes:
Immediate effects:
- Brief vasoconstriction (blood vessel narrowing) during the stretch
- Mediated by opioid receptors
Prolonged effects:
- Heart rate and blood pressure reduction lasting about 3 hours
- Brain blood vessel dilation lasting the entire observation period
- Mediated by nitric oxide (a natural blood vessel relaxer)
When researchers cut the trigeminal nerve branches, these effects disappeared. This confirmed the reflex pathway.
How It Works
The trigeminal cardiac reflex follows a specific nerve pathway:
- Sensory input: Facial stimulation activates trigeminal nerve endings
- Signal transmission: Signals travel through the Gasserian ganglion to the brainstem
- Processing: The brainstem integrates the signals
- Output: The vagus nerve signals the heart to slow down
- Brain effects: Blood vessels in the brain dilate
This process involves nitric oxide release. The researchers found that blocking nitric oxide production (using a substance called L-NAME) prevented the prolonged blood vessel dilation.
Brain Blood Vessel Behavior
The review describes interesting changes in brain blood vessel rhythm:
Under normal conditions, small brain arteries show rhythmic diameter changes at different frequencies. These rhythms relate to:
- Heart rate (around 1.0 Hz)
- Breathing (around 0.3 Hz)
- Muscle activity in vessel walls (around 0.1 Hz)
- Nerve activity (around 0.04 Hz)
- Endothelial cell activity (0.0095-0.021 Hz)
After jaw extension, the researchers observed increased activity in the frequency range related to blood vessel lining cells. This suggests the reflex activates the endothelium (the inner lining of blood vessels).
Practical Takeaways
- The trigeminal cardiac reflex affects both heart function and brain blood flow
- Cold water on the face activates this reflex (the diving reflex)
- Simple jaw stretching can trigger similar effects
- The effects on brain blood vessels can last for hours
- Nitric oxide plays a key role in the prolonged blood vessel dilation
Related Studies and Research
- Related Podcast Episode
- METABOLISM, THERMOGENESIS, AND BROWN ADIPOSE TISSUE
- HEADACHE AND MIGRAINE (COLD-BASED INTERVENTIONS)
- Health effects of voluntary exposure to cold water (review)
- Editorial: The trigeminocardiac reflex beyond the diving reflex
FAQs
What triggers the trigeminal cardiac reflex?
Any stimulation of the trigeminal nerve can trigger it. Common triggers include cold water on the face, surgical manipulation of facial structures, and jaw stretching.
Is this the same as the diving reflex?
The diving reflex is one form of the trigeminal cardiac reflex. When cold water contacts your face, it triggers this reflex through the trigeminal nerve pathways.
Could this have therapeutic applications?
The researchers suggest the prolonged effects on brain blood flow could have therapeutic potential. However, more research is needed before any clinical applications can be recommended.
Bottom Line
This review reveals that the trigeminal cardiac reflex does more than slow the heart. It also causes prolonged dilation of blood vessels in the brain. When researchers triggered this reflex in rats using jaw extension, brain blood vessels dilated for up to 3 hours. The effect depends on nitric oxide release from blood vessel lining cells. This research expands our understanding of why cold water on the face and other trigeminal nerve stimulation can have powerful effects on the cardiovascular system and brain circulation.
