Show Notes

What if the root cause of chronic illness is simply that your cells aren’t getting enough oxygen?

In this episode of The Dr Kumar Discovery, Dr. Ravi Kumar talks with Brad Pitzele, CEO of One Thousand Roads, with deep expertise in performance optimization and metabolic health. Together they explore how inflammation at the microvascular level creates oxygen bottlenecks, forcing cells into inefficient anaerobic metabolism, and how Exercise with Oxygen Therapy (EWOT) may offer a powerful way to break that cycle.

In this episode, you will discover:

• How inflammation causes endothelial swelling in capillaries, creating bottlenecks that starve tissues of oxygen
• The inflammation-hypoxia cycle and how EWOT disrupts it at the cellular level
• How gas laws, specifically Henry’s Law, explain why breathing concentrated oxygen during exercise dramatically increases tissue oxygenation
• Why exercise intensity amplifies the benefits of oxygen delivery beyond what rest or oxygen alone can achieve
• The connection between mitochondrial dysfunction, ATP production, and chronic disease
• How Otto Warburg’s research on cancer metabolism and inflammaging relate to oxygen deprivation
• Lyme disease and immune evasion as examples of conditions worsened by tissue hypoxia
• The 15-minute EWOT protocol (3 to 5 times per week) used by athletes and patients alike
• Clinical applications for long COVID, chronic fatigue, and exercise intolerance
• VO2 max improvements and athletic performance benefits
• Oxygen toxicity and safety considerations to be aware of

Key Takeaways

• Chronic inflammation causes endothelial swelling in capillaries, physically restricting oxygen delivery to tissues and forcing cells into less efficient anaerobic metabolism
• EWOT combines exercise with high-concentration oxygen breathing to overcome these microvascular bottlenecks and restore cellular oxygenation
• Henry’s Law explains why exercising while breathing concentrated oxygen pushes significantly more oxygen into tissues than either intervention alone
• The protocol is relatively simple: 15 minutes of exercise while breathing concentrated oxygen, performed 3 to 5 times per week
• Mitochondrial dysfunction from chronic oxygen deprivation may be an underlying factor in conditions ranging from long COVID and chronic fatigue to Lyme disease and cancer
• Olympic athletes use EWOT to enhance VO2 max, but the same principles apply to people struggling with exercise intolerance and chronic illness
• Safety awareness around oxygen toxicity is important, and proper protocols should be followed

Guest

Brad Pitzele is the CEO of One Thousand Roads. He brings deep knowledge of the science behind Exercise with Oxygen Therapy and its applications for both athletic performance and chronic disease recovery.

Transcript

[00:00 –> 00:11] Dr. Ravi Kumar: Welcome to the Doctor. Discovery. My name is Doctor. Ravi Kumar. And in today’s episode, we’re talking about something called EWAT, exercise with oxygen therapy.

[00:11 –> 00:38] Dr. Ravi Kumar: And honestly, I hadn’t heard of it until I started researching mitochondrial dysfunction and energy utilization. And what I found in the literature is fascinating. As we age, our tissues become less efficient at utilizing oxygen. Certain areas of our body become hypoxic, starved of oxygen, and this creates an environment where inflammation thrives. Cells can’t produce adequate energy, and degenerative diseases take hold.

[00:38 –> 01:11] Dr. Ravi Kumar: It’s a vicious cycle. Hypoxia drives inflammation, and inflammation drives hypoxia. EWAT, exercise with oxygen therapy, works on the premise that if you can break that cycle by flooding your tissues with oxygen, specifically during exercise when your body is primed to receive it, you can restore normal physiology to areas that have been compromised. My guest today is Brad Pittzley. He’s the founder and CEO of one thousand Roads, a company that makes EWAT systems accessible for home use.

[01:11 –> 01:36] Dr. Ravi Kumar: Brad came to this from his own health issues, autoimmune disease, melanoma, and eventually, Lyme’s disease, and he engineered his way to a solution that changed his life. Brad’s an engineer by training and extraordinarily knowledgeable about human biology and physiology. I think you’re really gonna like this episode. But before we get into it, I wanna give you some disclaimers. First, I’m a doctor, but I’m not your doctor.

[01:36 –> 02:02] Dr. Ravi Kumar: This show is for informational purposes only. My goal is to empower you with knowledge so you can take it and use it to better your health in partnership with your own physician. Second, this content is separate from my role as assistant professor at UNC. And third, we do talk about cancer in this episode, and I wanna be very clear. I’m in no way advocating for skipping or replacing traditional therapy prescribed by your oncologist.

[02:02 –> 02:21] Dr. Ravi Kumar: But you will hear that EWAT may be something that can enhance the effectiveness of treatment or support your resilience through the process of cancer treatment. It’s something you need to discuss with your doctor if you’re suffering with cancer. All right, with that said, let’s get into it. My name is Doctor. Ravi Kumar.

[02:21 –> 02:49] Dr. Ravi Kumar: I’m a neurosurgeon in search of the causes of human illness and the solutions that help us heal and thrive. I want you to join me on a journey of discovery as I turn over every stone in search of the roots of disease and the mysteries of our resilience. The human body is a mysterious miraculous machine with an amazing ability to self heal. Let us question everything and discover our true potentials. Welcome to the Doctor.

[02:49 –> 03:05] Dr. Ravi Kumar: Kumar Discovery. Okay. Welcome, folks. We’re here with Brad Pittsley. He is the owner, CEO, and founder of One Thousand Roads, which is a company that makes EWAT systems, which I’ve just told you all about.

[03:05 –> 03:21] Dr. Ravi Kumar: And I’m super excited today because this is a technology that most of us have never heard of. I haven’t heard of it, and I’m a neurosurgeon. So Brad, I’m really excited to have you on. Can you just tell us how you got into this field of exercise with oxygen therapy?

[03:21 –> 03:31] Brad Pitzele: Hey, Ravi. Thank you for having me. Yeah. They say necessity is the mother of invention, and that was true with me as well. I was incredibly sick.

[03:31 –> 03:57] Brad Pitzele: I developed autoimmune arthritis. The medications I was on for autoimmune arthritis eventually led to me developing melanoma. I went back to my rheumatologist after my melanoma diagnosis, and I asked him, I said, hey, what do I do here if I keep taking these drugs? I feel like I’m gonna die of cancer, and if I stop taking these drugs, I’m gonna die of autoimmunity. And he didn’t have a very good answer.

[03:57 –> 04:28] Brad Pitzele: He was like, well, let’s just keep testing drugs in the similar class, And that was very unsettling to me. And so as I kind of, I guess framed it in my head, said, I don’t like either one of these paths. There’s gotta be a third path forward that doesn’t involve so much risk of bad outcomes. And so that kinda took me off the beaten path, and I’d spent many years trying things, and nothing was working for me, Ravi. It was just I tried diets, I tried supplements, I tried different health modalities.

[04:28 –> 04:40] Brad Pitzele: If you name it, there’s a good chance I tried it. Nothing was working. I listened to other folks out there who had similar symptoms and were talking on groups across the Internet. I tried the things they were having success with. It didn’t work.

[04:40 –> 04:51] Brad Pitzele: And then I had a doctor suggest maybe I had Lyme disease. I was totally resistant to the idea. I’m like, there’s no way I have Lyme disease. I didn’t get bit by a tick. I didn’t have that bullseye rash.

[04:51 –> 05:16] Brad Pitzele: But half heartedly, I agreed to spend $500 on this Lyme test because I just wanted him to know I didn’t have Lyme, so we can move on and figure out the real issue. Well, the Lyme test came back that I had Lyme disease and Bartonella, which is a co infection you can get with Lyme disease. Actually, it’s the infectious agent that causes cat scratch fever, but causes so many other problems too. And I didn’t even believe it at first. I went back to him and said, what’s the chances this is a false negative?

[05:16 –> 05:28] Brad Pitzele: And he’s like, well, you have the DNA of these bacteria in your urine. It was a urine PCR, so what do you think are the chances? I’m like, oh, I guess I have to accept this one. But I didn’t get better. I tried a lot of things.

[05:28 –> 05:43] Brad Pitzele: You know, Lyme, one of the things they have to do is try antibiotics. I tried antibiotics. I tried so many things, herbs, supplement just so many things. But eventually, he recommended I look at oxygen, and that’s kinda how I stumbled and found my way into oxygen therapies.

[05:43 –> 06:07] Dr. Ravi Kumar: Well, so yeah. I mean, I think for the audience, a couple takeaways there is, you know, when you you had this arthritis of unknown etiology, you didn’t know what was causing it, so they’re putting you on immunosuppressive drugs. Yeah. And to to tone down your immune system or push down your immune system, thinking that your immune system was attacking your joints. But at the same time, our immune system is responsible for protecting us from cancer.

[06:07 –> 06:20] Dr. Ravi Kumar: We develop cancer cells almost every day in our bodies, and our immune system identifies them, gets rid of them. But because you’re suppressing your immune system, you develop melanoma, which I assume you’re in remission from now?

[06:20 –> 06:21] Brad Pitzele: Never had it again. Yeah.

[06:21 –> 06:52] Dr. Ravi Kumar: Okay. Good. So now you didn’t know what the arthritis was, but it turns out you have this infectious spirochete, which causes inflammatory arthritises arthritis, and you need your immune system to push it down and keep it at bay, but you were suppressing your immune system in Yeah. The setting of this infectious arthritis. And then we see this in medicine all the time, where you get in these vicious cycles of treating something that you don’t understand, and actually making it worse, and even putting your you in a potentially dangerous situation with cancer.

[06:52 –> 06:56] Dr. Ravi Kumar: So that’s very interesting, and it sounds like a real tribulation for you.

[06:56 –> 07:25] Brad Pitzele: Yeah, I actually got, I mean, and I kinda short handed it, but like, they would put me on these meds, they would work for six months, they’d stop working, I’d be worse than when I started them. They would double the dose, They’d help get me a little bit further up, but never where I originally was, and I just kinda kept stair stepping down. You know, at one point, it had gotten so bad, I had all these new aches and pains. The backs of my legs felt like I’d just run a marathon. The bottoms of my feet felt like I’d just had them beaten with a meat hammer.

[07:25 –> 07:39] Brad Pitzele: And I would go back to the rheumatologist and say, this is arthritis, right? And he’s like, no, that’s not arthritis. And I was like, what is he talking about? This is the same stuff, I can tell, But like, it didn’t have the same name, and so I could I was just accumulating symptoms faster than they had names, really.

[07:39 –> 07:44] Dr. Ravi Kumar: Right. And so when they When your doctor recommended Oxygen, what was the thought behind that?

[07:44 –> 08:04] Brad Pitzele: Well, he was a big believer in Oxygen. He used ozone therapies, and he’d actually tried some ozone therapies on me, a particular type of ozone therapy where you inject ozone into the blood after you remove it from the body and reinject it into your body. And he that was like his big dog. He’s like, this is the thing that works for everyone. It’s expensive, but it works.

[08:04 –> 08:29] Brad Pitzele: And it did nothing. I mean, no difference. And in Lyme, sometimes when you have an impact on the Lyme, you kill a bunch of it. You have a symptom called a Herxenheimer reaction, which is basically if you kill enough Lyme spirochetes at once, they dump like a toxic payload into your body, a substance called acetaldehyde, which is the same substance you get when you’ve got a hangover. So you feel like you’ve got a hangover, you’ve got a flu.

[08:29 –> 08:58] Brad Pitzele: And, you know, it’s kind of actually a nice thing when you have Lyme. You’re like, oh, I found something that’s killing Lyme, so now I just need to back off and keep doing it, and I’ll make some progress, and it didn’t even do that. So I was pretty, you know, crestfallen. So he’s like, you know, Brad, my last recommendation to you would be oxygen therapies. And that was kinda like the last arrow in his quiver, if you were, and, you know, so that was kinda what he left me with, and I I wasn’t gonna leave any stone unturned at this point, because it was it was getting pretty scary and dark.

[08:58 –> 09:21] Dr. Ravi Kumar: Yeah. And the and the thought is that Lymes, which is a spirochylobacteria, is microaerophilic or anaerobic, and it doesn’t like oxygen. Correct? And so there’s tissues that it can hide out in that are low oxygen environments where the immune system doesn’t operate very well in those environments either. The immune system relies on ox oxygen for forming oxidative bursts to kill microorganisms.

[09:21 –> 09:31] Dr. Ravi Kumar: It also needs oxygen to properly run its electron transport system and make energy and fight infection. So Lyme’s really benefits from low oxygen environments.

[09:31 –> 10:00] Brad Pitzele: Yeah, you nailed it. Lyme disease is really intelligent. I mean, when people try to, like, we like to think of ourselves as the apex of the evolutionary chain. When you start to study some of these bacteria and realize how incredibly intelligent they are, and how they’re manipulating our bodies for their own benefits, it’s really eye opening. So what Lyme will do is it will cause an inflammatory reaction in your body, and when your immune system responds, it causes collateral damage to your own tissues.

[10:00 –> 10:24] Brad Pitzele: And then what Lyme does is it uses these damaged tissues and it goes intercellular, so it goes inside the cell wall and hides in this damaged cell. The cell is too sick, it’s just trying to survive. It’s actually in a low oxygen environment called hypoxia, which Lyme disease loves. Your immune system most of your immune system can’t go inside the cell. There are components that work within the cell, but a lot of them don’t.

[10:24 –> 10:51] Brad Pitzele: It hides from the immune system, and then, I mean, it does so many intelligent things, like it rearranges its outer surface protein. If you think back when we were dealing with COVID, everyone remembers the spike proteins. The spike proteins were these proteins on the outside of the virus, and the immune system, it’s a lock and key mechanism. The immune system feels this spike protein and says, oh, I know what this is. This relates to this infectious agent, and then it mounts its attack.

[10:51 –> 11:13] Brad Pitzele: Well, Lyme will keep changing its outer surface protein, so it always looks different to the immune system. So it’s incredibly clever at how it evades it, and it all does come down to having to live in a low oxygen environment where the immune system is underpowered, and as you stated, the immune system really needs a lot of oxygen to do its work.

[11:13 –> 11:17] Dr. Ravi Kumar: This is why people use hyperbaric oxygen therapy for Lyme’s disease, correct?

[11:17 –> 11:17] Brad Pitzele: That’s

[11:17 –> 11:30] Dr. Ravi Kumar: But that is an extraordinarily expensive, time consuming, needs big equipment, and a lot of time to do. So how did you discover EWAT, and how did that fit into your treatment?

[11:30 –> 12:21] Brad Pitzele: Yeah, I first looked at hyperbaric because it was the oxygen therapy I’d heard of, And it was at the time, you know, this is a decade ago, it was gonna cost $75,000 or more to do it in the Dallas area where I am. But the doctor knew of a place in Florida I could fly out and do it, and it would maybe only be 30 to $50,000. Still a lot of money, plus you had to fly out there, and it was like a seven week treatment, seven days a week, and you had to find place to stay for seven weeks, and I, you know, I knew I couldn’t keep my job with that. And it’s very time consuming too. The protocol is ninety minutes inside the pressurized chamber, plus you need time to pressurize and depressurize, plus time to get to the doctor’s office, because the hard shell hyperbaric are not the sort of soft shell things you see athletes doing.

[12:21 –> 12:41] Brad Pitzele: They’re medical devices that require oversight. It’s both time and cost prohibitive. I always say like hyperbaric is a really good heroic treatment. Like, it’s something you could do maybe for four or six weeks, but once you start getting, you know, for a lifestyle treatment, it becomes challenging because of the time it takes, much less the the cost.

[12:41 –> 12:44] Dr. Ravi Kumar: Okay. So is that where EWOC kinda came into your life?

[12:44 –> 13:05] Brad Pitzele: Yeah, so then the next thing I started looking at is this thing called EWAT, Exercise with Oxygen Therapy. I had never heard of it. But as I started to research it, it’s, it was really kind of refreshing. You can do it in like fifteen minutes. It just involves doing fifteen minutes of cardiovascular with a mask on your face that’s delivering near pure oxygen.

[13:05 –> 13:22] Brad Pitzele: And so rather than sixty or ninety minutes, it was fifteen minutes. So immediately that was a win for me because, you know, I had brain fog. I had energy issues on top of all the pain at this point, and I was fighting for my job. And like, I couldn’t afford to go take all this time off. So fifteen minutes fits inside.

[13:22 –> 13:27] Brad Pitzele: You know, I felt like, hey, that’s something I could do in the morning before I go to work, and and, you know, make this happen.

[13:27 –> 13:30] Dr. Ravi Kumar: Okay. And you’re an engineer, correct?

[13:30 –> 13:53] Brad Pitzele: Yeah, that’s true. So when I first started looking at it, the challenge I had with EWAT was a lot of the companies selling it, there was a lot of hyperbole. Everything was hyper super mega awesome. The price tags were really high, 5 to $25,000 for a system. And I’d spent so much money on experiments trying to get better, and this was a high price.

[13:53 –> 14:08] Brad Pitzele: I, know, if I knew it was gonna work, I would’ve found that money in a moment flat. But, know, for an experiment, it was just too much for me. There weren’t really much reviews on EWOD at the time. There wasn’t a whole lot of folks talking about it. There wasn’t much out there to find other than what the companies themselves were saying.

[14:08 –> 14:21] Brad Pitzele: So I didn’t have a lot of faith, to be honest, and so I just started doing some research. I’d spent ten years of my career in engineering, and I decided to put that to work, and I just kinda designed my own system. Okay.

[14:21 –> 14:23] Dr. Ravi Kumar: So you built a system, you started using it on yourself?

[14:23 –> 14:26] Brad Pitzele: Yeah, that’s right.

[14:26 –> 14:28] Dr. Ravi Kumar: And did it work? I mean, were you seeing benefits?

[14:28 –> 14:47] Brad Pitzele: Yeah, you know, I was in really bad shape, so it wasn’t an overnight. We do see customers who have really fast responses. I wasn’t one of them. It probably took me three months before I was certain I was noticing. I was probably noticing benefits before then, but at the three month mark, I was like, this isn’t just like things coming and going like they sometimes did for me.

[14:47 –> 15:01] Brad Pitzele: This is like stepwise improvement. My brain fog and energy was one of the early things that I noticed. I was like, wow. I can pay attention in in meetings again and like be meaningfully engaged with the kids a little bit more. I mean, I’m not crashing quite as much.

[15:01 –> 15:12] Brad Pitzele: And then after that, eventually came all the aches and pains, and all the other 47 symptoms that were lingering around. It was really quite amazing. It’s just oxygen, and like, I’ve been breathing oxygen my whole life.

[15:12 –> 15:21] Dr. Ravi Kumar: Yeah. Exactly, and I think there’s some very interesting physiology around EWOT that we’ll definitely talk about. So, I mean, now, how are you? Are you feeling normal?

[15:21 –> 15:32] Brad Pitzele: Yeah, I’m 99% better. Lyme, you know, I don’t think you ever really get rid of Lyme, it’s very good at evading the immune system, it’s probably in my body, but it does not affect me day to day at all.

[15:32 –> 15:42] Dr. Ravi Kumar: Okay. That’s really cool. Hey, guys. I created this podcast because there’s too much confusion out there. There’s too much noise, too many conflicting messages about our health.

[15:42 –> 15:59] Dr. Ravi Kumar: My goal was simple when I made this podcast. I wanna cut through all of that and give you information that you can actually use. If that resonates with you, here’s how you can help. Leave a rating and a review on Apple Podcasts. Share an episode that resonated with you with someone else that you care about, and that’s how this show grows.

[15:59 –> 16:10] Dr. Ravi Kumar: That’s how we reach more people who are searching for answers. Thanks for being a part of this, and I appreciate your help. So let’s just say, so you built this system, you started a company, it’s called One Thousand Roads. Yep. What does it look like?

[16:10 –> 16:17] Dr. Ravi Kumar: I mean, because no one’s most of my audience have never heard of it. If Yeah. You were to describe it to them, visualize it, what would it look like?

[16:17 –> 16:25] Brad Pitzele: Well, so we use a machine called an oxygen concentrator, and what it does is it purifies the oxygen in the air around you. It’s an electrical device.

[16:25 –> 16:25] Dr. Ravi Kumar: Okay.

[16:25 –> 16:45] Brad Pitzele: And it’s about, you know, 18 inches wide, 24 inches tall, nine inches thick. Plug it into the wall, flip a switch on, and it produces 93% pure oxygen. Now, compare that to the oxygen in the room. At sea level, oxygen’s about 21%. So at like four and a half times the concentration of oxygen.

[16:45 –> 17:01] Brad Pitzele: Now the problem with these machines, we have two different models. They either put out five liters of oxygen a minute or 10 liters of oxygen a minute. But when you’re exercising, oxygen. You can use like 50 or 60 liters. So these machines can’t keep up with your exercising.

[17:01 –> 17:11] Brad Pitzele: So what we do is we use the machine to fill a buffer. We call it a reservoir. It looks like an oversized balloon. Let’s say it’s roughly six feet by six feet. It can hold a thousand liters.

[17:11 –> 17:27] Brad Pitzele: Think of a two liter bottle of soda, think of 500 of those sort of things. So it’s a big big amount of oxygen. So we use these devices to fill that reservoir, and then we hook up a hose from that reservoir to a mask that you wear, and you wear that mask and do exercise.

[17:27 –> 17:32] Dr. Ravi Kumar: Okay. And so you’re on, what, a stationary bike or a treadmill?

[17:32 –> 17:53] Brad Pitzele: You can do any sort of exercise you like. Our preference is for cardio. So any piece of cardio equipment, use I an elliptical, people use rowing machines, treadmills, stationary bikes. We have folks who are really sick, they’ll use those under the desk pedal bikes as they start, they’ll use a rebounder, they’ll do aerobics. We even have people using it while they’re weight training.

[17:53 –> 18:09] Dr. Ravi Kumar: Okay. So they’re wearing this rebreather mask that’s attached to a bladder full of oxygen that’s being filled by a oxygen concentrator, and I assume you have to turn this on before you start to fill up the bladder. And then how much cardio are you doing, or or exercise? Fifteen minutes. Fifteen minutes.

[18:09 –> 18:09] Dr. Ravi Kumar: Yeah. Okay.

[18:09 –> 18:10] Brad Pitzele: Not too much.

[18:10 –> 18:14] Dr. Ravi Kumar: And that and that’s the process of basically exercise with oxygen therapy.

[18:14 –> 18:25] Brad Pitzele: That’s it. It sounds intimidating, and when sometimes when folks will look at what an EWAT system looks like, they’ll at first be intimidated, and then we always get these messages from customers who are shocked at how easy and simple it is.

[18:25 –> 18:32] Dr. Ravi Kumar: Okay. Very cool. Okay. Let’s talk about how this came about. Because, you know, it had to have come from somewhere.

[18:32 –> 18:44] Dr. Ravi Kumar: It’s not like someone just said, hey, let’s breathe oxygen while we exercise, we’ll get better. There had to be some science behind it, and there’s a really cool story here. I thought maybe you could go into the historical and scientific history of this device.

[18:44 –> 19:05] Brad Pitzele: Yeah, so the history goes back to actually the nineteen twenties. Otto Warburg won the Nobel Prize for some research he did on oxygen, and the research was around oxygen and cancer. He could take any typical cell and deprive it of oxygen and make it cancerous. So that was kind of an moment. He won the Nobel Prize for it.

[19:05 –> 19:37] Brad Pitzele: Meanwhile, in the nineteen sixties and seventies, a gentleman named Manfred von Ardene from Austria, he was an Austrian inventor and physicist. Now this guy, he was really well known. He helped commercialize television in the nineteen thirties, and then later he actually built the first scanning electron microscope. So really prolific inventor. And he decided he wanted to look at some Otto Warburg’s work, and he started doing research around oxygen therapies, and started doing exercise with oxygen therapy.

[19:37 –> 20:09] Brad Pitzele: And so he’s considered the godfather of EWA, and he had this one really amazing discovery. Research to this day is really bearing this out. The common, most frequent term we use nowadays that wasn’t around when he started doing research is something called inflammaging. So as we age, you know, we become more and more inflamed, and the expectation in our society is now that we’ll just keep becoming more inflamed. What he found is this inflammation occurs inside of our circulatory system, inside the endothelial cells, which are the cells that line our blood vessels.

[20:09 –> 20:45] Brad Pitzele: They become inflamed as well, and every year past the age of 25, we lose 1% of our body’s ability to utilize oxygen because of this inflammation. Now, if you think about our circulatory system, the end run of the circulatory system, really where the rubber meets the road, where the blood actually transfers nutrients and oxygen to the cells, is at the capillaries. And these things are thinner than a human hair. I mean, they’re tiny. And what he found was the endothelial swelling in the capillaries was swelling them shut, so red blood cells couldn’t get through.

[20:45 –> 21:06] Brad Pitzele: Now, what happens downstream of that is all the tissue downstream is starving for oxygen, and the medical term we use for that is called hypoxia. So they’re all hypoxic. They’re all starving for oxygen. And if you look at a cell, and we’re gonna get into the mitochondrial health, so now this cell doesn’t have oxygen. What it does is it switches to survival mode.

[21:06 –> 21:33] Brad Pitzele: It goes from aerobic respiration, which is producing energy using oxygen, to anaerobic respiration, which is producing energy in the absence of oxygen. And the problem with that is a couple fold. One, it’s about 20 times less efficient. So these cells go from fully energized to basically in survival mode. They don’t have enough energy to even fully operate, and they’re cutting out a lot of essential functions.

[21:33 –> 21:58] Brad Pitzele: And one of the things they even stop doing is they stop taking the trash out. They stop detoxifying. They just let all of this metabolic waste build up inside the cell wall. And to add insult to injury, when you’re doing anaerobic respiration, you produce a massive amount of metabolic waste, much more than with aerobic. So now you’ve got all this waste product causing further damage to a cell that can’t repair itself.

[21:58 –> 22:30] Brad Pitzele: So it’s a vicious cycle. So what Manfred von Arden discovered, which was really the birth of EWAT, was that by doing EWAT, he was able to create this anti inflammatory effect inside of the capillaries in the endothelial cells that reopened the reopened the capillaries and allowed normal blood flow. And the way it works is actually pretty fascinating. It works through a couple ways. One, the immediate way you’re able to get oxygen through that blockage is we drive oxygen into our blood plasma.

[22:30 –> 22:43] Brad Pitzele: So if you look at your blood, it’s really there’s three main components if we were to simplify it. There’s red blood cells. These are the units that carry oxygen. That’s their primary responsibility. There’s white blood cells, which is our immune system.

[22:43 –> 23:15] Brad Pitzele: And then there’s blood plasma, which is this clearish brown liquid that the red blood cells and white blood cells ride on. It’s mostly water, but it also carries our nutrients, etcetera. Now normally, plasma doesn’t carry much oxygen, maybe like two to 3% of the oxygen in your body. But under certain conditions, we can actually drive oxygen into that plasma and utilize it to increase the oxygen carrying capacity of the blood. So EWAT drives oxygen into the plasma.

[23:15 –> 24:08] Brad Pitzele: So the first way it helps with this endothelial swelling is that plasma is a thousand times thinner than a red blood cell, so it’s able to get past those blockages and create downstream oxygenation and also oxygenate those endothelial cells. But then number two, that anti inflammatory effect lasts after you’re done doing EWAT, and now you’ve reestablished normal blood flow where red blood cells can get through there. And so one of the biggest pieces of research that really struck me, what he did, was he had elderly people who had a lot of endothelial swelling in their capillaries do just a few sessions of EWAT, and then he had them come back many weeks later, and he saw that their capillaries were still reopened. Normal blood flow was still reestablished and at a more youthful level. And so that was kind of the moment, which is, hey, we don’t have to live with this inflammaging in our capillaries, we can reverse it.

[24:08 –> 24:30] Dr. Ravi Kumar: Yeah. And that’s really cool because you’re coming down to a basic physiological principle that can be modified through technology. I I love that, you know? And one thing for the audience, you know, this swelling of the endothelial cells, it’s well established. When they are hypoxic, every cell in our body has these sodium potassium ATPase pumps.

[24:30 –> 24:56] Dr. Ravi Kumar: They’re these pumps that pump sodium out of our cells and potassium into our cells, and it creates these electrical gradients, whether you’re talking about a nerve cell or any cell in your body. And that’s how we run everything. We use ATP to basically pump solutes and electrolytes against their gradients. When you don’t have oxygen, you can’t make the ATP. Because when you don’t have oxygen, with every glucose molecule, you make two ATP.

[24:56 –> 25:20] Dr. Ravi Kumar: When you have oxygen, you make 36 ATP with each glucose molecule. And oxygen is basically, all it does is it’s a sink for electrons. It sits at the very end of the electron transport chain, and it receives the electrons. And without that, everything backs up, and you can’t make the the ATP you need. So that’s why you die within minutes of not having oxygen, because everything in your body shuts down.

[25:20 –> 26:10] Dr. Ravi Kumar: But if you’re not having oxygen, just these micro environments, the ends of these capillaries that are not getting good blood flow, well, those cells, they can’t pump the sodium out of the endothelial cells can’t pump the sodium out, and so where sodium stays, so does water. That’s why they say, you know, if you’re bloated, eat less sodium because you’ll retain less water. Well, these endothelial cells are retaining sodium, they’re retaining water, they’re swelling, they’re blocking off those capillaries, which then reduces blood flow even more, they become more hypoxic, it’s this vicious cycle. So once Ardene Von Ardene gave them oxygen, he opened up the cells, then red blood cells are flowing through there, oxygenating, and it’s reestablishing a normal physiological circulation in these microenvironments. And I think it’s just completely fascinating that he discovered that.

[26:10 –> 26:19] Dr. Ravi Kumar: And I think it’s it’s a toll tragedy that we don’t know about it after going through medical school, or in the general medical community, you know? This is something very basic.

[26:19 –> 26:39] Brad Pitzele: I couldn’t agree more. It’s such a cool thing when you realize it, and again, you’re like, wait a second, this is just oxygen. But it makes so much sense when you get down to it, to your point. It’s like, we all know instinctively, and what we’ve been told in school is, there won’t be life on Earth really without oxygen. Just maybe single cell organisms here and there, but like, you couldn’t have this proliferation.

[26:39 –> 26:54] Brad Pitzele: Well, that’s what you described. It’s two ATP versus 36. That’s nearly a 20 fold increase in energy. So Yeah. The other interesting thing I learned, Ravi, as I dove into it was red blood cells, they’re actually bigger than your your capillaries.

[26:54 –> 27:37] Brad Pitzele: Before you have any swelling in your capillaries, the only way for a red blood cell to fit through a capillary is it has to fold on itself, kinda like a taco, to get into the capillaries. And they’re designed to do this, which is fascinating, actually amazing in itself that our bodies came up with this method where cells are folding to get into the end runs. But as we get sick, and we get inflamed, and as we age, they lose their flexibility. And actually, as we get sick, sometimes the variability of the size of them becomes bigger as well, so you have more oversized red blood cells that can’t get in there. And so, to your point, it becomes one of these things where your body starts fighting against itself, and then as they become too stiff, they need to get filtered out of our our system.

[27:37 –> 27:59] Brad Pitzele: So our spleen, which is responsible for this, it starts filtering out these inflexible red blood cells, and now your body needs to spend a bunch of energy creating new red blood cells. You’re diverting a lot of energy now into just having a functioning circulatory system, rather than actually going and protecting your bodies. It was the downward spiral I actually experienced, to be honest.

[27:59 –> 28:22] Dr. Ravi Kumar: I mean that’s fascinating. Yeah, and that inflexibility of the red blood cells is one of the reasons why people with sickle cell anemia develop these crises, because their blood vessels, their red blood cells can’t fold to get into these small spaces. So that’s a very well established principle. Hey everybody, I’m building an app called sharemytrial.com, and I need your help. The idea for this app is simple.

[28:22 –> 28:43] Dr. Ravi Kumar: What if we could crowdsource health solutions? Real people sharing what actually worked for their health problem, and a community that validates what has worked on a larger scale. That discovery that someone made about their migraines, their sleep, their energy, it shouldn’t stay locked in their heads. It should reach you. So if you’re interested in helping me make this happen, go to sharemytrial.com and sign up to be a beta tester.

[28:43 –> 29:03] Dr. Ravi Kumar: And together, we can build something that democratizes health discovery. Cheers. Talk to me a little bit about, because I think this is essential to EWAT, the oxygen carrying capacity of plasma. Talk to me about that, and how Henry’s Law fits in here, and how you use EWAT to manipulate that part of our physiology.

[29:03 –> 29:23] Brad Pitzele: Sure. So Henry’s Law is is the principle on which all this works. So the reason why EWAT works, it’s actually the same reason why hyperbaric oxygen works. If if you were to put a little device called a pulse oximeter on your finger to measure your red blood cells, they’re at capacity. That number will read 99%, 98%.

[29:23 –> 29:49] Brad Pitzele: There is no room for more oxygen in your blood. The issue isn’t do I have enough oxygen in my blood. The issue is is enough oxygen getting delivered to all the tissues in my body that is needed? But it’s tapped out. But through Henry’s Law, which has nothing to do with medicine or science, it’s actually a chemistry law, and what it basically states is the larger the partial pressure of the gas on top of the liquid, the more of it’s gonna go into a solution.

[29:49 –> 30:32] Brad Pitzele: So what that means is in both hyperbaric oxygen and in EWAT, what we’re doing is we’re driving a massive amount of oxygen through our lungs and into our bloodstream, and the larger volume of oxygen we can bring into our bodies, the more of it’s gonna go into solution into the blood plasma. And so that actually increases the carrying capacity of our blood. And secondarily, as we said, plasma is so much thinner, so much smaller than a red blood cell that it doesn’t have to rely on that deformability of the red blood cells, or, you know, having wide open capillaries. It can get into, let’s just call it, all the nooks and crannies of the circulatory system and provide oxygen to places that otherwise might not be available for them.

[30:32 –> 30:54] Dr. Ravi Kumar: Right. Okay. So basically, you know, if you’ve ever put a pulse oximeter on your finger, it says 97, 98, 99, if you’re doing good, if you’re in the healthy range. And that is the saturation of oxygen in the red blood cells stored in hemoglobin, which is a protein that stores oxygen. So that’s the primary oxygen carrying capacity in our circulation.

[30:54 –> 31:18] Dr. Ravi Kumar: But the plasma is untapped, essentially. And so by using an increased partial pressure of oxygen, which is basically breathing 93 oxygen through this mask in the EWAT system, we are increasing how much oxygen is being carried in that plasma and reaching areas that the red blood cells may not be able to get to because of inflammation in the endothelial cells of the capillaries. Is that right?

[31:18 –> 31:21] Brad Pitzele: That’s exactly right. That’s exactly right.

[31:21 –> 31:37] Dr. Ravi Kumar: Very cool. So we’ve talked about the chemistry or the physics of getting this oxygen into the plasma, but a big part of EWOT is exercise. That’s the e in the EWOT. And how does that synergize with giving a higher partial pressure of oxygen? Because I think this is really fascinating.

[31:37 –> 31:40] Dr. Ravi Kumar: We You are pulling a huge lever here with exercise.

[31:40 –> 31:51] Brad Pitzele: Yeah. Yeah. Yeah. This is this is actually the coolest part about it. So when you exercise, your body naturally immediately goes into what I’ll call an oxygen starvation state.

[31:51 –> 32:28] Brad Pitzele: Your cells recognize we don’t have enough oxygen to maintain this level of muscular activity. And so your body in all of its infinite wisdom has all these physiological adaptations to allow it to continue exercising. Like, immediately when you start exercising, what happens? You start breathing deeper and faster. So you’re bringing more volume of air, or in this case, 93% oxygen into your lungs, but also the membrane of your lungs, which is that thin layer that separates the outside, the air and the oxygen, from your blood, it thins out to allow a greater diffusion or more oxygen to pass through.

[32:28 –> 33:00] Brad Pitzele: On the other side of the lungs, there’s what’s called greater capillary recruitment, which means you have all these capillaries waiting to take oxygen. Most of the time, a lot of them are not filled with blood, because it’s not necessary. But they’re they’re kind of like excess capacity. But when you start exercising, your body knows it needs them, so it starts sending blood to them, and they start diffusing oxygen at a greater rate. So now, we’ve just brought in not only higher purity gas, 93% oxygen versus 21, but a greater volume of it.

[33:00 –> 33:34] Brad Pitzele: So to your point, now we’re driving more and more into the plasma, and that’s just the start of it, really, because then your body has all of these things that are happening inside your circulatory system that also optimize for oxygen delivery. Your heart starts beating faster and deeper. The net result, I think, is your cardiac output, the amount of volume your blood pumps during exercise, can be 300 to 500% of what it is at rest. Wow. So now your blood is just flowing super fast through your body, and then there’s a couple other things that happen I think are really cool.

[33:34 –> 34:02] Brad Pitzele: One is there’s what’s called vasodilation. Simply means all of your blood vessels start opening up to allow for more of this blood to flow. And that’s double important because obviously more blood flow means more oxygen, but we just talked about these endothelial cells that are choked off. We’ve just started to open those up a bit even with the exercise, this vasodilation. And then the last one that I think is really important is your systolic blood pressure goes up.

[34:02 –> 34:49] Brad Pitzele: So normally we think of increased blood pressure as dangerous, but in exercise it’s not. It’s a really good response for us. The increased blood pressure, best way to think about that is it’s actually like the mode of force that drives oxygen from your blood and into your tissues. The greater the pressure differential between your blood and your tissues, the more it’s able to drive that gas out, so deeper into the tissues. And so you have all these physiological changes that are stacked for maximizing oxygen consumption and oxygen delivery, and then you start breathing near pure oxygen, so it’s such a beautiful synergy because we’re really leaning into how the body is supposed to work, and we’re consuming oxygen at the exact moment when the body is thirsting for it, and it’s most receptive to it.

[34:49 –> 35:04] Dr. Ravi Kumar: Right. That’s a really cool synergy, honestly. So compare that to hyperbaric oxygen therapy. Not opposed to hyperbaric oxygen therapy, I think it’s a fascinating technology, but there are some big differences here because of the exercise I

[35:04 –> 35:26] Brad Pitzele: think hyperbaric’s a really amazing treatment. I think there’s times when there are use cases where I think actually it’s probably a better use case for some folks. What happens in hyperbaric is you lay inside of a pressurized tube while you’re breathing near pure oxygen. So from that perspective, you’re breathing similar oxygen. Most common setting is at 2.3 ATA, which is 2.3 atmospheres.

[35:26 –> 35:46] Brad Pitzele: So what that means is if you’re standing at sea level, you’re experiencing one atmosphere of pressure. You’ve got one atmosphere above you. Inside this tube, it’s 230% that number. So a 130% more pressure. Now the soft shells you see athletes and celebrities using at home, those usually go to 1.3 or 1.5 ATA.

[35:46 –> 36:15] Brad Pitzele: So they’re like 30 or 50% more pressure. So when you’re doing the hard shell and you got a 130% more pressure, you’re breathing four and a half times more oxygen than you were when you were standing in the room. Number two, we talked about pressure differential driving diffusion. In this case, it’s diffusion across the lung membrane, you’ve got a 130% more pressure, you’re driving that much more gas across your lung membrane. So more pure gas, higher pressure is driving more into your body.

[36:15 –> 36:52] Brad Pitzele: Now, the difference is, you’re lying on your back, or you’re stationary. Once that oxygen gets in there, it’s also using Henry’s Law. So it’s also diffusing into the plasma, so all the benefits you hear about from hyperbaric oxygen are simply derived from, or primary all of them, are derived from being able to drive oxygen into your blood plasma similar to EWAT. Now, a couple things that happen different is number one, you don’t have a circulation booster. But what actually happens is your body, when you’re in a hyperbaric chamber, it senses this massive supply of oxygen coming into your blood.

[36:52 –> 37:15] Brad Pitzele: And it knows it’s more than it should need for being stationary. And so it also tries to meet homeostasis. Homeostasis isn’t just about increasing oxygen consumption and demand, it’s about also balancing it when we are sedentary. And so what it does is it causes vasoconstriction. And what that means is instead of causing your blood vessels to open up, it causes them to clench closed a bit.

[37:15 –> 37:38] Brad Pitzele: And that’s to try to limit the amount of oxygen. Now even with that vasoconstriction, there’s more oxygen flow meeting the tissues, and because it’s in the plasma, it’s able to get to places that have been choked off. So that’s why it still provides benefits, but you’re fighting against your body. Your blood pressure doesn’t go up consummate with the pressure in the hyperbaric chamber. So as I said, there’s a 130 more pressure in the hyperbaric chamber.

[37:38 –> 37:57] Brad Pitzele: That’s all held back by your lung membrane. If it was allowed to pass through your lung membrane and you had 130% more pressure in blood vessels, that would be a problem. So thankfully, doesn’t. Your blood pressure does go up a little bit with hyperbaric. It’ll go up like five or 10%, and that’s been measured in studies time and again.

[37:57 –> 38:11] Brad Pitzele: But you compare that to what your blood pressure rise when you’re doing exercise, which is 50 or more percent, it’s much smaller. So it does have a little bit of a rise, but you’re also fighting your body with that vasoconstriction.

[38:11 –> 38:30] Dr. Ravi Kumar: Right. Okay. You know, the other thing I think it’s interesting here is that when you’re exercising, you’re taking advantage of Bohr’s Law too, which when you use oxygen, you create carbon dioxide. That’s why we breathe in oxygen, we breathe out carbon dioxide. Plants do the opposite with photosynthesis, and it’s this beautiful synergy in the world.

[38:30 –> 39:02] Dr. Ravi Kumar: But when we our cells release carbon dioxide, it causes the hemoglobin molecules and to release more oxygen. So you’re you’re pulling more oxygen out with exercise in addition to all those physiological effects you talked about there. Whereas in hyperbaric oxygen therapy, you’re just sitting there, you’re laying there sedate, you’re not moving. And there’s no increased metabolic activity, so you’re not taking advantage of this increase in efficiency of oxygen transfer. So I I just thought that was very interesting.

[39:02 –> 39:30] Dr. Ravi Kumar: Hyperbaric oxygen therapy is very important for people who have pressure sickness, if they go down, dive down deep, and they come up too quick, they can develop the It’s very important for treatment of anaerobic skin infections and wound infections, where you need like the atmospheric oxygen touching the tissues. So those are all things where it can be very important. But as far as penetrating oxygen deep into the tissues, nothing beats EWOT, based on my review of the literature.

[39:30 –> 39:52] Brad Pitzele: I would agree with that. And we we hear that, I guess what you’d call clinically, we hear that from our customers all the time, because there’s also risk profile differences. So when you’re doing hyperbaric oxygen, there’s a variety of risks that don’t exist with EWAP because of the pressure. You could have a sudden depressurization event, which can be very dangerous. You can have issues with ears, with eyes, etcetera.

[39:52 –> 40:25] Brad Pitzele: And then we have folks who just have like panic attacks because they’re stuck in this tube, or they’re afraid someone’s not gonna be able to get them out. And we’ve had all sorts of customers who come to us, not just because it was too expensive, but because they’ve had those sorts of issues, and usually they come to us and think we’re like, know, EWAT’s like second fiddle. Well, I can’t do the thing I really want, so I guess I’ll try you as a, you know, second best sort of thing. And I can’t tell you how many of those folks have come back, and just told us like, hey, I can’t believe the results I’m seeing here. It’s so dramatic, and it’s so much faster than I would have expected.

[40:25 –> 40:36] Dr. Ravi Kumar: Yeah. Well, that’s cool. Okay. So let’s transition over to the actual practical applications and kind of results you’ve seen. There is not a ton of research on EWAT.

[40:36 –> 40:46] Dr. Ravi Kumar: There is research out there. I reviewed, like, 47 papers over the last couple weeks on it, but and some of them are in German, So from von Ardene, thank god for Google Translate. You know? We can read anything now.

[40:46 –> 40:47] Brad Pitzele: Yes.

[40:47 –> 41:23] Dr. Ravi Kumar: But as far as the oxygen in the body, I mean, and physiology and degenerative disease and infectious disease, there’s just a ton of research. Some of it’s on hyperbaric oxygen therapy, but a lot of it’s on just application of oxygen, basic physiological mechanisms. And we connect those two, and we understand it in a physiological and practical sense, and that’s where we kinda come up with a lot of the data on EWAT. I think a lot of clinical trials need to be done, but that being said, I don’t ever discount n of one trials. That means you did it, what was your results?

[41:23 –> 41:38] Dr. Ravi Kumar: And then you add those all together, and you get this consensus of likelihood. So tell me, what’s going let’s start first with degenerative disease. What have you seen with your patients, and what do you know about the literature in the setting of EWOT and degenerative disease?

[41:38 –> 42:24] Brad Pitzele: We have customers who are using EWOT for a variety of health concerns, and seeing some really amazing results. Things like cancer, cognitive decline, and specifically Alzheimer’s, Parkinson’s, stroke recovery, concussions, infectious illnesses, Lyme disease, long COVID, autoimmunity, and so many others. So I think the literature is becoming more and more crystallized around the fact that most chronic illness either is caused by or has a component of mitochondrial dysfunction. And the mitochondria are the parts of our cells that use oxygen to produce energy. Unfortunately, they’re also some of the most fragile organelles inside of our cells.

[42:24 –> 43:01] Brad Pitzele: They get damaged most easily. They have a lot of challenges with oxidative stress just because of the role they play in the cells, etcetera. And so when they become damaged, there can be kind of this chain reaction where symptoms and so forth kind of fold upon themselves and cause more problems. Now, as far as research, there’s quite a bit of research on oxygen and cancer. As we spoke about early in the show, Otto Warburg early on discovered that he could turn cells cancerous by depriving them of oxygen, but even more modern research is showing a strong linkage between oxygen and cancer, like variety of cancers.

[43:01 –> 43:32] Brad Pitzele: They’ve shown time and again, whether it’s breast cancer or other sorts of hard tumor cancers, that the survival rate of people with that cancer is directly proportional to the oxygen status of the tumor. And so if you have more oxygen in that tumor, you have less likelihood of cancer overcoming you. It really makes a lot of sense to your point. What happens in a lot of cancerous cells is they use anaerobic respiration, glycolysis is what they call it. So that’s producing energy in the absence of oxygen.

[43:32 –> 44:01] Brad Pitzele: They also kind of hijack your body. So your body then tries to overcompensate by angiogenesis, which is basically a process where it develops new blood vessels. It’s trying to create new blood supply to get oxygen in there. Right. And then the cancer cells hijack that, they cause angiogenesis, and when those new blood cells arrive, they use it as a highway for them to metastasize to other parts of the body.

[44:01 –> 44:34] Brad Pitzele: So when you can resupply oxygen, one of the first things you can do is turn off some of the angiogenesis so that they’re not creating these super highways of metastasis and cancer spread. But also, we have folks who use EWAT as part of a holistic protocol, and then we have folks who actually use it as an augmented traditional protocol. So they’re doing chemotherapy and radiation treatments. Now, these treatments are radiation, or excuse me, they’re oxidation treatments. And so what that means is they rely on oxygen to be successful.

[44:34 –> 45:17] Brad Pitzele: They can oxidize the cancer, which is basically a chemical reaction they use to break down and kill the cancer. And so people are using them, and there seems to be some research that shows that oxygen status of the tumors improves success of a lot of these drugs, but then the drugs themselves cause some pretty nasty side effects. Most folks are aware of that, and a lot of that has to do with some of the damage that they cause. And so oxygen is a really strong detox detoxifier. So in order to break down toxins within our body, we need to oxidize, which is an oxidative reaction basically to break down a complex molecule into a simpler molecule that our our livers, our kidney, our elimination organs can use to get it out of the body.

[45:17 –> 45:55] Brad Pitzele: And so a lot of folks will use EWAT even just for the detoxification benefits. And to your point about clinical results, I’ve seen so much where folks have talked about how their chemo brain has gone away, how they’re no longer feeling the side effects of it and they can go on with their life. So there’s a ton of linkage between oxygen and cancer, and definitely a lot of what I’ll call clinical feedback from customers saying, hey, I’ve used this and it’s done amazing things. I’ve heard some just some really cool stories, and that’s really heartening, because we all know that’s big C, cancer, something like that, in our society, it’s just like it has an over, overweighted shadow on all of us. Like, gosh, I hope I don’t have that when I’m so.

[45:55 –> 46:23] Brad Pitzele: Right. And when you get that, it’s such a psychological, traumatic experience for a lot of folks. Another place where they’ve started to do some research, University of Dayton has started to do some research on using EWAT for long COVID. So in long COVID, one of the main symptoms a lot of folks face is chronic fatigue, just crippling fatigue, and you know, I had that same thing with Lyme. We have folks with chronic fatigue syndrome and fibromyalgia who’ve had that as well.

[46:23 –> 46:47] Brad Pitzele: And again, at the root of fatigue is mitochondrial function, not having enough energy production, and the number one gating nutrient, so to speak, in producing more energy is oxygen, because of that 20 to one multiplier, it gives you an energy production. And so there is research also showing mito mitogenesis when you have, you know, increased oxygen supply in cells versus hypoxia. So

[46:47 –> 46:50] Dr. Ravi Kumar: Which is increase in mitochondria formation.

[46:50 –> 47:22] Brad Pitzele: Yeah, which is the the birth of new mitochondria. So your cells, when they become damaged, and obviously, as I mentioned, the mitochondria become damaged first, they are now in this survival state. They can’t produce new mitochondria. But if you can reoxygenate them, the mitochondria that are surviving, one of the early things they’ll do is, as they’re starting to repair is produce more mitochondria to meet that increased supply so that they can maximize that. And then once they have the energy to do that, the next thing they can start doing is producing new healthy cells that they don’t have to repair.

[47:22 –> 47:40] Brad Pitzele: So this energy is so important in that kind of natural renewal that happens in our bodies. And so people long COVID, the other one they have often is exercise intolerance. So that would sound contraindicated for EWAT, right? Got exercise intolerance, you don’t wanna do exercise. But that’s actually where we have the most research in EWAT.

[47:40 –> 48:19] Brad Pitzele: Believe it or not, EWAT’s been used for many decades from Olympic athletes and others, and you know, the US Olympic team and the Russian Olympic team have done so much research on EWOT to improve athletic performance right down to things like v o two max. V o two max is is the number one indicator of your cardiovascular capabilities. So if you’re looking at an elite athlete and you wanna measure one metric to figure out how in shape they are, let’s say, it’s v o two max. And that literally stands for the volume of oxygen, the maximum amount of volume you can take in. Because obviously, that’s the gating factor in energy production, which is necessary to continue exercise.

[48:19 –> 48:59] Brad Pitzele: And so what actually naturally happens, and most folks will notice this within their first couple sessions of doing EWAT, is they’ll notice exercise feels easier with the mask on. And so if you’re exercise intolerant because you have long COVID, you can barely think about walking up the stairs, now we put this mask on and have you walk on a treadmill, and you’re like, you know, day one, you’re thinking you’re only gonna do four minutes, but you just did six. And then you do it a few more times, and you’re at ten minutes, and then, you know, you come back and talk to us in three months, and you tell us how you’re jogging, and this is incredible sort of thing. And so a lot of some early research going on there, but a lot of good results we’re seeing out in the real world. And that’s also chronic fatigue.

[48:59 –> 49:25] Brad Pitzele: It’s very much the same. Lyme disease, you know, we’ve helped a lot of folks with Lyme disease. I’m patient number one or customer number one on that one, I can tell you. My recovery’s been nothing short of miraculous for my life, just the quality of life improvement there. And the research around Lyme disease, the University of Texas, I believe it was years ago, on using hyperbaric oxygen for Lyme, and showed great improvements in symptomology, etcetera.

[49:25 –> 49:59] Brad Pitzele: And so I tend to tell folks that there’s a lot of research on hyperbaric oxygen that you can drag and drop across because effectively the body doesn’t know inside of it that there’s pressure outside. It just knows more oxygen’s coming through the lungs, and we’re both using the blood plasma, so oxygen’s getting every bit as deep, and probably deeper with EWAT. There’s obviously, again, there’s a lot of experience and lived data with folks in oxygen. As you pointed out, there’s a lot of research that shows the spirochete that causes Lyme, Borrelia burgdorferi, is anaerobic. It can’t live in an oxygen rich environment.

[49:59 –> 50:26] Brad Pitzele: Once you And it also can’t live in an inflammation low environment. And the research on oxygen and inflammation is absolutely fascinating. This was like an moment for me, like I have to keep doing this, I have to make this a priority, like this seems dumb not to, but the research is really clear. Anywhere in your body you have hypoxia, low oxygen, oxygen starvation, you have inflammation. And anywhere you have inflammation, you have low oxygen.

[50:26 –> 50:51] Brad Pitzele: It’s your whole point about the sodium potassium. Naturally, as we get older, as Van Arden showed us, we lose 1% of the ability to utilize oxygen. It causes this cascade of less oxygen, and oh, well, lo and behold, now we’ve discovered this thing called Inflamma Ageing, which is we all just get more inflamed, just coincides with less oxygen. And so, one of the quotes I learned was from a gentleman named Arthur Guyton. He wrote the textbook on medical physiology.

[50:51 –> 51:13] Brad Pitzele: And so this is a medical physiology textbook that’s been in use by doctors for fifty years, and I read this quote right around that same time, which is, At the root of all disease is a lack of oxygen. And we all know today, at the root of all diseases, what we say is inflammation is basically at the root of every disease we talk about. Well, look at that interesting intersection.

[51:13 –> 51:43] Dr. Ravi Kumar: I think that’s absolutely true. I mean, inflammation is probably the root of almost every chronic disease, literally. You know, whether you’re talking about cardiovascular disease, cancer, neurodegenerative diseases like Alzheimer’s, metabolic disease like diabetes, all these diseases have their roots in inflammation. And inflammation can’t exist without essentially hypoxia. And you know, there’s a chicken and an egg there, is did, you know, the inflammation cause the hypoxia, or did hypoxia cause the inflammation?

[51:43 –> 51:53] Dr. Ravi Kumar: And I think that those two things exist in this on this seesaw, where one pushes the lever, then the other pushes the lever that drives us into disease states, essentially.

[51:53 –> 52:01] Brad Pitzele: And we know you can start at any side of that circle and cause the other thing, and then it just Yeah. It spins. So as as soon as you can cut off the circle, you’re in a good spot.

[52:01 –> 52:27] Dr. Ravi Kumar: This is very interesting. So we that was a lot, but let’s just sum it up. There, you know, we’re talking about the use of EWAT in degenerative diseases like neurodegenerative, cardiovascular, joints, all these things where low oxygen environments can cause disease in specific organs. There’s athletic performance enhancement, increasing b o two max in athletes, or even people who have chronic fatigue, or long COVID. There’s infectious disease applications.

[52:27 –> 52:48] Dr. Ravi Kumar: There’s cancer applications, and all these come down to the fact that you are increasing the metabolic efficiency of energy production in these cells Yeah. And allowing these tissue tissues to naturally heal. Because one thing I love to tell all my patients and all the people I talk to is that, hey, the body wants to naturally heal.

[52:48 –> 52:48] Brad Pitzele: Right.

[52:48 –> 53:08] Dr. Ravi Kumar: It just gotta get out of its way, you know? And when you do, you give the it the tools to heal, the oxygen in this situation, the body will naturally heal. And I think that’s why you see so many applications to EWAT. Because, you know, when people hear, oh, there’s this one technology, it does all these things, you get a little skeptical. I get skeptical.

[53:08 –> 53:09] Brad Pitzele: Mhmm. Yeah.

[53:09 –> 53:33] Dr. Ravi Kumar: But when that one technology is acting on one basic piece of physiology, human biology, that is universal through every cell, every mitochondria in our whole body, it makes sense. Makes sense that if you increase energy production efficiency in your cells, you will restore a state of health. And I think that’s why EWOD is so powerful.

[53:33 –> 53:59] Brad Pitzele: Yeah, I know, and that’s what early on I used to say, I never understood why all these companies were using hyperbole. Said, the hardest part about marketing EWOD isn’t come up with benefits, it’s to figure out which benefits to talk about, because when people hear all of them, it’s kind of overwhelming, it’s almost unbelievable. But I guess, kind of the way I I rationalized it in my head is like, if there was one nutrient that you felt would have the most benefit on your body, kinda makes sense it’d be oxygen.

[53:59 –> 54:08] Dr. Ravi Kumar: I mean, you can’t you can’t survive for minutes without it. I mean, literally, minutes after you lose access to oxygen, you’re gone from this world. Your biology stops functioning.

[54:08 –> 54:11] Brad Pitzele: That’s right. Yeah. It’s it’s impressive.

[54:11 –> 54:29] Dr. Ravi Kumar: And it makes sense. So, okay, let’s talk about protocols. How do you when people buy a system from you, which Yeah. By the way, is extraordinarily affordable for something like this, how do they start using it? What would you tell them, hey, here’s what you should do, here’s how you should get into it, here’s what to expect.

[54:29 –> 54:31] Dr. Ravi Kumar: Give me that Yeah. Explanation.

[54:31 –> 54:59] Brad Pitzele: Perfect. So I’ll start with the end state where we like you to get to. And not everyone gets here, but if we can, we’d like to get you to do a fifteen minute session of cardio, three to five times a week, and kind of our eventual goal output would be to get to maybe like 70 or 80% of your theoretical max heart rate. This is not high intensity interval training, it’s less. But 70 to 80%, and by the way, guess we should step back and say how do you calculate that?

[54:59 –> 55:17] Brad Pitzele: So the way you calculate your theoretical max heart rate is you take the number two twenty, and you subtract your age. So if you’re 40, you would take two twenty minuteus one forty, that’s a 180 beats per minute. That’s your 100% mark. You wanna do 70 to 80% of that. And the reason is, this is for general wellness.

[55:17 –> 55:46] Brad Pitzele: Now if you’re trying to optimize athletic performance, I would guide you a little bit different. But most folks, it’s all about general wellness and general health. This is a really good meeting place, 70 to 80% of your theoretical max. Consistent effort, not high, low, because you’re really increasing your cardiovascular output, you’re driving that vasodilation. There is a point at which you exercise too hard, and you start to produce a lot of oxidative stress, you break down your tissues more than you’re helping.

[55:46 –> 55:50] Brad Pitzele: And so we’re trying to kinda get you up, but not over the hump, so to speak.

[55:50 –> 55:54] Dr. Ravi Kumar: So basically, zone two cardio is what you’re aiming for.

[55:54 –> 55:54] Brad Pitzele: Yeah, that’s right.

[55:54 –> 55:59] Dr. Ravi Kumar: It’s cardio that you could, if you didn’t have a mask on, you could still have a conversation and do.

[55:59 –> 56:31] Brad Pitzele: That’s right. That’s right. When you’re starting, most folks can start and get right into it. If you’re sick, you know, because we do have a lot of folks with a lot of health challenges, most of them do fine, but some of them do end up having what we call a detox reaction if they start too fast. So as I mentioned, your cells that are hypoxic develop all this metabolic waste inside the cell wall, and now you reoxygenate it, and they start dumping all this waste into your bloodstream, and it overwhelms your elimination organs, your kidneys, and your bladder, and all of your systems can’t deal with it.

[56:31 –> 56:53] Brad Pitzele: And so it just kinda gets backlogged in your circulatory system, and you just start kinda feeling sick. You feel like you have the flu, or you feel a little under the weather and gross. No one wants to deal with that, and you don’t need to. So for folks who are really sick, what we do recommend is you start slow and you build up. So, you know, day one, if you’re really sick, day one might just be breathing the oxygen for a few minutes.

[56:53 –> 57:27] Brad Pitzele: Successive sessions, you add a minute or two until you get to fifteen minutes of stationary breathing. And once you know you can do that, then at the very end, the last minute, you switch it from stationary to some light cardio, and then you work that back until you can do fifteen minutes of light. And then over time, as I mentioned, the exercise is easier. Even for folks who are like, I can’t do any exercise, they’re amazed that they can do more than they thought they would, and how quickly their cardiovascular conditioning will improve, much more than if they were just doing the exercise. So over time, we build towards that.

[57:27 –> 57:34] Dr. Ravi Kumar: Okay. The end goal is to be able to do fifteen minutes 70 to 80% of max heart rate, three to five times per week.

[57:34 –> 57:35] Brad Pitzele: That’s right.

[57:35 –> 57:35] Dr. Ravi Kumar: Okay.

[57:35 –> 57:51] Brad Pitzele: And that’s it. And it’s really simple, you know. And that’s, I think that’s actually the beauty of it, is once you figure it out, and you know, after you’ve done it your first time, you’re like, this is easy, I can go do Right. For some of us, for me actually, was a time savings, because I used to do thirty minutes of cardio, and now I do 15, and I get more benefits out of it.

[57:51 –> 57:55] Dr. Ravi Kumar: And this just sits in your home next to your exercise bike or your treadmill.

[57:55 –> 57:55] Brad Pitzele: That’s right.

[57:55 –> 58:13] Dr. Ravi Kumar: Yeah. You just get up, you do it, and it’s done. Don’t have to go to a health spa or anything like that. Okay. So tell me, what should people expect to see after they’ve got to this goal of three to five times a week at 70 to 80% max heart rate, fifteen minutes?

[58:13 –> 58:39] Brad Pitzele: So the first thing I think folks notice, the very first thing they notice is the exercise is easier. You will probably notice that on your first session if you’re paying attention, you’ve exercised before. The next things people tell me they notice are clear head, better memory, and better sleep. There is research related to sleep quality and oxygenations, and that’s another place where it helps quite a bit. So yeah, energy, clear headed, and sleep are very quick for a lot of folks.

[58:39 –> 58:55] Brad Pitzele: Some folks notice differences after their first session. They’re just shocked and they’re in love with it. Other folks take a few sessions to start noticing it, but certainly after a few weeks, pretty much almost everyone except for, like, me, who took a little bit longer because I was so sick, and I’m I’m an outlier in that respect.

[58:55 –> 59:05] Dr. Ravi Kumar: Yeah. Okay. Now what about people who are healthy, but they just want to achieve their maximal fitness level? Can they use this as a tool for that?

[59:05 –> 59:25] Brad Pitzele: Oh yeah, we have college and professional athletes who are using this with great success. You know, both folks who are competitive, and you know, kinda weekend warriors. So this is actually where the body of research is, deepest direct research on this. EWAT will improve your power output. It will improve your endurance.

[59:25 –> 59:45] Brad Pitzele: It will improve your v o two max. It will reduce your lactic acid burden. So that’s important because when your body goes, as we said, aerobic to anaerobic, meaning at this point you’re exercising and you’re using your muscles more than your body’s able to bring oxygen to them. Now they’ve gone anaerobic. They produce lactic acid, that’s that forty eight hour muscle delay.

[59:45 –> 01:00:17] Brad Pitzele: You went to the gym for the first time, and two days later you can’t move, that’s damage the tissues. So now not only do you have to repair all of the tissues from the normal exercise, you also have to repair it from the incremental damage of the lactic acid. Now, in order to get rid of lactic acid, what your body needs, not surprising, oxygen. Oxygen turns lactic acid and breaks it down into energy for us. So number one, when you’re doing EWAT, you’ll have less lactic acid build, and number two, you can use it to clear it out.

[01:00:17 –> 01:00:45] Brad Pitzele: So people who are using EWAT for performance will use it for one of two ways generally. One is they’ll use it during their hard sessions. So maybe they’re like, let’s say you’re an endurance athlete, what you would do is you would use EWAT in one of your tight endurance sessions, because you’ll be able to put out more power output. But I’ll give myself as an example here. When I started doing EWAT, I definitely wasn’t trying to be a performance athlete, but I would do cardio on my elliptical machine.

[01:00:45 –> 01:01:09] Brad Pitzele: It had 20 levels of resistance, and I’d do it at a level 12. So I got on that first day, and I put that mask on, and I was like, this is kinda easy, so the next time I ramped it up to 13, and halfway through, I was like, nope, 14. A few weeks later, I was like, no, 15. Today, I’ll do it at like a 17 out of 20, which is kind of ridiculously high, but I don’t feel like I’m, you know, killing myself. Just feel like I’m the same level of effort.

[01:01:09 –> 01:01:39] Brad Pitzele: Yeah. The important thing is every once in a while, I forget to fill my reservoir, and I’ll go out there to do cardio, I’ll just go do the cardio, and I’ll do it at 17 without the oxygen. Athletes will use this to increase their endurance and their ability to do more work, train harder, so to speak, and that will carry over for when they’re not doing EWAT. The second way is for recovery. So as I mentioned, the oxygen can be used to break down the lactic acid, give those cells more energy so that they can do all of their work to recover and repair themselves.

[01:01:39 –> 01:02:11] Brad Pitzele: And so then what we have folks do is go out, do your whole training session, whatever that thing is, and then do EWOD at the end to blast out any lactic acid and hasten the recovery. I personally do that when I weight train, and I was shocked because, you know, I might miss a week or two of weight training because I’ve traveled or something, and I’ll come back and do weight training, and I’ll do a little bit of EWAT afterwards, and I’ll never get that muscle soreness. And I’m like, how is a guy in his forties not have muscle soreness when he did in his twenties and thirties? It doesn’t make any sense. Right.

[01:02:11 –> 01:02:15] Brad Pitzele: And even to this day, I kinda laugh. I feel like I I cheated the system a little bit when I do that.

[01:02:15 –> 01:02:18] Dr. Ravi Kumar: And you’re just metabolizing out the lactic acid right away, is that what’s happening?

[01:02:18 –> 01:02:51] Brad Pitzele: That’s exactly right, you’re metabolizing it out, and because of that, I put on a lot more muscle, not because I was trying to grow, but because, you know, I would just wanna do three sets of 10 of whatever I was doing, and from a time constraint I didn’t wanna do 15 or 20 reps of whatever it Right. So because I was recovering faster, I was able to put more weight on faster just to kinda keep at that same thing. And so that kinda shocked me a little bit too. I was doing this to try to recover my health, and I found all these fitness benefits. I had a doctor, he wanted to do a bioenergy test on me after I was doing EWOT for eighteen months.

[01:02:51 –> 01:03:39] Brad Pitzele: And this is like a mitochondrial health thing that he did, and it was like basically I’d sat at rest, they measured my blood pressure and my respiration rate, and then they had me do the exercise bike until until failure is what they called it, until my heart rate and everything got up to a certain point, they called it failure. I was 41 at the time. My v o two max came back, and it was like 50, which was like, on a bike is like top 5%, I guess. You know, like, my metabolic rate, my fat burning rate, all these things, they were at like a 100% mine rut, 200%, a 150, a 160% of It what they was really the lady who did the test, she came back to me, and she’s like, after I got done, she was shocked. She’s like, it’ll take you about eight minutes to get to get to failure, and that sixteen minutes I’m still going, and at twenty two minutes, twenty four minutes it finally fails, and I got off.

[01:03:39 –> 01:03:47] Brad Pitzele: She’s like, are you like an ultra endurance athlete or what are you? And I was like, no, I’m just trying to recover my health. I’m definitely not doing ultra endurance.

[01:03:47 –> 01:03:49] Dr. Ravi Kumar: Did he publish that study?

[01:03:49 –> 01:03:57] Brad Pitzele: No, I’ve got the I’ve got the I was actually looking at the results, I just cracked them open for the first time in years yesterday, I was looking at it. I was like, oh my gosh, I had forgotten.

[01:03:57 –> 01:04:00] Dr. Ravi Kumar: Yeah. That would have been a good case study.

[01:04:00 –> 01:04:03] Brad Pitzele: It makes me wanna go back and do my VO two max again sometime soon and see what

[01:04:03 –> 01:04:18] Dr. Ravi Kumar: So it is what if people wanna try an EWAT system, but they don’t wanna buy one right away. You know, they’re not You know, they hear this, they’re convinced about it, but they’re like, gosh, you know, I wanna I would like to try it before I actually go buy one.

[01:04:18 –> 01:05:13] Brad Pitzele: That’s that’s great. We have a lot of folks who do that. We don’t keep a database of people who who use our systems in clinics, but they are using clinics. Clinics. They’re in doctor’s offices, chiropractor clinics, recovery clinics, all sorts of places, even fitness centers. The easiest way to do it usually is you can Google EWAT near me, or EWAT near my zip code, and usually you’ll be able to find some around there. Most of those would be good. I always tell folks kinda EWAT is EWAT. We don’t sell the Coca Cola. We sell the Coke can. The magic’s in the oxygen in your room. We just purify and store it. The only thing I would watch out when you do that is make sure they’re using an EWAT system with a reservoir. There’s some older systems where they were just trying to use the concentrator, but if you’re getting 20 liters of oxygen but you need 50, you’re diluting the benefit. And Von Arden did a lot of research on that, and actually, at those dilution levels, you end up needing to do hours to get to the same benefit of fifteen minutes, and no one’s gonna do hours of cardio.

[01:05:13 –> 01:05:23] Dr. Ravi Kumar: Yeah, right. The one thing I wanted to ask you as well, and some people might have, might be thinking about this if they’re in the health field, is there any risk of oxygen toxicity with this?

[01:05:23 –> 01:05:48] Brad Pitzele: It’s a great question. And you were talking about Bohr’s Law earlier. So there is no risk of oxygen toxicity with EWA, and there’s two reasons for it. So what happens in oxygen toxicity, what it is, is basically oxygen gets trapped in our circulatory system. And so if you were just sitting on the couch breathing oxygen from a mask, it would take probably more than twenty four hours to get oxygen toxicity at normal pressure.

[01:05:48 –> 01:05:57] Brad Pitzele: Right? If you’re doing EWAT, you will take in a massive amount of oxygen. The thousand liters is equivalent to twelve to twenty four hours of normal oxygen use.

[01:05:57 –> 01:05:59] Dr. Ravi Kumar: In fifteen minutes. In fifteen minutes, you

[01:05:59 –> 01:06:16] Brad Pitzele: can take in the same amount. It’s the same amount you’d take in ninety minutes in a hard shell hyperbaric chamber. So it’s a massive amount of oxygen. So it’s worth asking the question, is oxygen toxicity risk? Number 1,000 liters still is not quite enough to hit that toxicity limit by itself.

[01:06:16 –> 01:06:56] Brad Pitzele: But the more important part is, even if it were, you couldn’t get oxygen toxicity with EWA, and that’s that amazing synergy with exercise. Because, as you were stating, when you exercise, you produce a massive amount of carbon dioxide, and we think of carbon dioxide as that waste gas, and it is. When we’re producing energy, we have this waste gas, carbon dioxide, but it does something else inside of our circulatory system. It builds up and creates a pressure in our circulatory system, and that pressure would drive oxygen out of the circulatory system and into the tissues. It’s one of those magical ways the body has found to use its waste to drive more fuel, so to speak.

[01:06:56 –> 01:07:02] Brad Pitzele: And so even if you could do EWAT for three hours, you still couldn’t get oxygen toxicity. There’s no risk.

[01:07:02 –> 01:07:08] Dr. Ravi Kumar: Brad, how can my audience find you? If they wanna explore more about your product, what should they do?

[01:07:08 –> 01:07:11] Brad Pitzele: The easiest way is to go to bradtalkshealth.com.

[01:07:11 –> 01:07:11] Dr. Ravi Kumar: Okay.

[01:07:11 –> 01:07:23] Brad Pitzele: And we’ve got some free resources for you there. You can learn more about EWAT, and you can also go to our YouTube channel, and we’re putting up weekly videos to talk about the science of EWAT and red light, so.

[01:07:23 –> 01:07:28] Dr. Ravi Kumar: Okay, very cool. And I guess the final question I wanna ask you is, why’d you call it 1,000 Roads?

[01:07:28 –> 01:07:56] Brad Pitzele: Yeah, so when I was sick, I was in a really dark place at points. I was kinda felt like the light was dimming, like my capabilities kept coming down and down, and my hope was going down with it too. When you’re really sick, I think hope is like, is your last weapon, and when it starts to fade, it gets really kind of scary. I felt like everyone had a 25,000 or a $50,000 solution or a test for me to try. Come try this thing, it’s $50,000.

[01:07:56 –> 01:08:22] Brad Pitzele: Yeah, it’s the same thing as a car, but wouldn’t you do it if it would improve your health? And I remember a doctor actually said this to me once, and I remember thinking, well yeah, if I knew it was gonna work, I’d figure it out. I’d mortgage the house and pay you twice that if I had to, but I don’t know if it’s gonna work. So to plunk down $50 on every experiment, there’s only so many of those that are gonna happen. I felt like I was bleeding in the water with sharks around me, a lot of folks looking to take advantage of me.

[01:08:22 –> 01:08:57] Brad Pitzele: And so when my doctor started seeing I was getting better, he suggested maybe I start selling them to his patients. I wanted to create a company out of gratitude for my healing, and kind of paid it forward, and made it made it more available for folks. Brought the price down, brought science first versus hyperbole first, but also respected the fact that everyone’s got their own health journey, and so it was kind of an homage to wanting to help a thousand people recover their health so that they didn’t have to be in that dark place I felt like I was at my worst, but also respecting the fact that everyone’s journey is their own, and I’ll have to kind of walk through it and take ownership for our own health.

[01:08:57 –> 01:09:14] Dr. Ravi Kumar: Well, that’s fantastic, man. I think you did a great job. I think engineers play crucial roles in advancing medical science. I know in my field they have. I mean, an engineer basically developed the VP shunt with Roald Dahl, and that has helped countless people with hydrocephalus.

[01:09:14 –> 01:09:41] Dr. Ravi Kumar: And here you are, you took engineering, you took your need for something to make your life better, and you developed a system that’s affordable and available to people. So that’s really cool. I’m gonna put your contact information, the links that you mentioned in the show notes, so my audience can get in contact with you, learn more from you. But this has been fantastic. I’m gonna start I’m gonna order a system and start using it, because I’m really excited about it, especially after all the research and talking to you.

[01:09:41 –> 01:09:49] Dr. Ravi Kumar: It’s really one of those fantastic levers that we can pull to increase metabolic efficiency, and I’m really looking forward to it.

[01:09:49 –> 01:09:52] Brad Pitzele: Awesome. We’re excited to have you. Yeah. Thank you for having me on the show.

[01:09:52 –> 01:09:54] Dr. Ravi Kumar: Yeah. Cheers, Brad. Thanks for coming on.

[01:09:54 –> 01:09:55] Brad Pitzele: Thank you.

[01:09:55 –> 01:10:10] Dr. Ravi Kumar: So I hope you enjoyed that conversation with Brad Pittsley. Here’s what I find compelling about EWOT. It operates on a fundamental principle of physiology. Inflammation and hypoxia are codependent. Where you find one, you’ll find the other.

[01:10:10 –> 01:10:42] Dr. Ravi Kumar: They reinforce each other in a cycle that underlies much of chronic disease. EWAT breaks that cycle. When you exercise, your body creates the ideal conditions for oxygen delivery. Increased cardiac output, vasodilation, and elevated blood pressure driving diffusion of oxygen into the tissues. And when you breathe concentrated oxygen during that window, you’re saturating not just your hemoglobin, but also your plasma, which allows oxygen to reach areas that red blood cells can’t access due to capillary inflammation.

[01:10:42 –> 01:11:10] Dr. Ravi Kumar: The science makes sense. The practical application is straightforward, and the potential applications from chronic fatigue and long COVID to athletic performance and age related degeneration all trace back to that same mechanism, which is restoring oxygen to tissues that need it. It’s a simple and powerful technology and another piece of knowledge you can stick in your back pocket in case you need it. So thanks for listening, and until next time. Stay curious, stay skeptical, and stay healthy.

[01:11:10 –> 1:11:12] Dr. Ravi Kumar: Cheers.